merck millipore,默克密理愽
  • merck millipore,默克密理博,ABC66,Anti-Vacuole membrane protein 1 Antibody (VMP1)

  • merck millipore,默克密理博,ABC66,Anti-Vacuole membrane protein 1 Antibody (VMP1)

    产品名称：Anti-Vacuole membrane protein 1 Antibody (VMP1)
    产品型号：ABC66
    This Vacuole membrane protein 1 antibody is validated for use in WB & ICC for the detection of the Vacuole membrane protein 1 protein.

    merck millipore,默克密理博,ABC66,Anti-Vacuole membrane protein 1 Antibody (VMP1)

  • 产品介绍
  • merck millipore,默克密理博,ABC66,Anti-Vacuole membrane protein 1 Antibody (VMP1)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABC66
    描述 Anti-Vacuole membrane protein 1 Antibody (VMP1)
    Alternate Names
    • Transmembrane protein 49
    • Vacuole membrane protein 1
    背景信息 Vacuole Membrane Protein 1 (VMP1) is a transmembrane protein that co-localizes with LC3, a marker of the autophagosomes. It interacts with Beclin 1, a mammalian autophagy initiator, through the VMP1-Atg domain, which is essential for autophagosome formation. VMP1 expression induces the formation of ultrastructural features of autophagy and recruitment of the microtubule-associated protein 1 light-chain 3 (LC3), which is inhibited after treatment with the autophagy inhibitor 3-methiladenine. VMP1 is induced by starvation and rapamycin treatments. Its expression is necessary for autophagy, because siRNA VMP1 inhibits autophagosome formation in both aforementioned autophagic stimuli.
    产品信息
    格式 Affinity Purified
    控制
    • HeLa cell lysate treated with Rapamycin.
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Vacuole membrane protein 1 antibody is validated for use in WB & ICC for the detection of the Vacuole membrane protein 1 protein.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Vacuole membane protein 1 (VMP1) in HeLa cells treated with Rapamycin.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminal Topological Extracellular Domain of human Vacuole membrane protein 1 (VMP1).
    表位 C-terminal Topological Extracellular Domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the C-terminal Topological Extracellular Domain of Vacuole membrane protein 1 (VMP1).
    品种反应性 RatHuman
    Species Reactivity Note Demonstrated to react with Human.
    Predicted to react with Rat based on 100% sequence homology. Other homologies: Mouse (95% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_112200
    基因符号
    • HSPC292
    • VMP1
    • TDC1
    • TMEM49
    纯化方法 Affinity Purified
    UniProt编号
    • Q96GC9
    UniProt汇总 FUNCTION: Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.

    SUBUNIT STRUCTURE: Interacts with BECN1. Interacts with TJP1.

    SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Endoplasmic reticulum.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate treated with Rapamycin.

    Western Blot Analysis: 1 µg/mL of this antibody detected Vacuole membrane protein 1 (VMP1) in 10 µg of HeLa cell lysate treated with Rapamycin.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABC66,Anti-Vacuole membrane protein 1 Antibody (VMP1)

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