- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA, IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1431 Replaces 04-1095 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Interferon-β Antibody Alternate Names - IFN-beta
背景信息 Interferon beta is a globular protein consisting of 5 alpha helices with a predicted molecular weight of 20 kDa. Due to glycosylation, however, the observed molecular weight is closer to 25 kDa by SDS-PAGE. 产品信息 格式 Serum 控制 - IFN expressing cell lines
演示 Rabbit Serum diluited with PBS. Liquid containing no preservatives. 应用 应用 This Anti-Interferon-β Antibody is validated for use in ELISA, IH, IP, NEUT, WB for the detection of Interferon-β. 主要应用 - Western Blotting
- ELISA
- Immunohistochemistry
应用说明 Interferon neutralization: 2 x 10e5 neutralization units/mL where one neutralization unit is the amount of antiserum required to neutralize one unit of human interferon beta (Hu-IFN-b) to a 50% endpoint. Interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," in J. Virol., Vol. 37, 755-758]; [Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon," in Methods of Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon about 1 unit/mL of interferon is the quantity necessary to produce a cytopathic effect of 50%. The units are determined with respect to the international reference standard for human interferon beta provided by the National Institutes of Health [see Pestka, S. (1986) "Interferon Standards and General Abbreviations," in Methods in Enzymology (S. Pestka, ed.), Academic Press, New York 119, 14-23]. This material is prepared specifically for the effective neutralization of human interferon beta.
Immunohistochemistry
Western blot: 1:5000
Immunoprecipitation
ELISA
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Recombinant human interferon beta expressed in E. coli 宿主 Rabbit 特异性 Recognizes Human interferon beta. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000600.1
基因符号 - IFNB2
- IL6
- HSF
- BSF-2
- HGF
- IL-6
- BSF2
- CDF
纯化方法 Unpurified UniProt编号 - P05231
UniProt汇总 FUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
SIZE: 212 amino acids; 23718 Da
SUBCELLULAR LOCATION: Secreted.
PTM: N- and O-glycosylated.
DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.
SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 20000 units
上一件merck millipore产品：merck millipore,默克密理博,324708,Endoproteinase Asp-N, Excision Grade, Pseudomonas fragi
下一件merck millipore产品：merck millipore,默克密理博,05-23-3703,Laminin Nonapeptide - CAS 110590-60-8 - Calbiochem
相关产品
merck millipore,默克密理博,559300,Safingol - CAS 15639-50-6 - Calbiochem
merck millipore,默克密理博,ECM425,Collagen-Specific Integrins Investigator Kit
merck millipore,默克密理博,MAB2513,Anti-Integrin α1β1 Antibody, clone RA1.1
merck millipore,默克密理博,324708,Endoproteinase Asp-N, Excision Grade, Pseudomonas fragi
merck millipore,默克密理博,05-23-3703,Laminin Nonapeptide - CAS 110590-60-8 - Calbiochem
merck millipore,默克密理博,SF-1126,miR-197-3p; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,ABC66,Anti-Vacuole membrane protein 1 Antibody (VMP1)
merck millipore,默克密理博,14-487M,Cdk3/Cyclin E Protein, active, 250 µg
merck millipore,默克密理博,AB9122,Anti-DOPA Decarboxylase Antibody