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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC468 描述 Anti-MAGEA3 Antibody/MAGE3 Alternate Names - MAGE-3 antigen
- Melanoma-associated antigen 3
- Antigen MZ2-D
- Cancer/testis antigen 1.3
- CT1.3
背景信息 MAGEA3/MAGE3, also known as Melanoma-associated antigen 3, Antigen MZ2-D, Cancer/testis antigen 1.3, CT1.3, MAGE-3 antigen, and encoded by the gene MAGEA3/MAGE3, is an interesting protein with multiple roles. MAGEA3/MAGE3 is primarily an accessory protein that assists in ubiquitin ligase activity of E3 ubiquitin protein ligases. MAGEA3/MAGE3 enhances the ligase activity of TRIM28, but also acts to stabilize various E2 conjugating ubiquitin enzymes with the E3 target protein. Developmentally, MAGEA3/MAGE3 plays a role in growth promotion, and hence, it also plays a role in tumor transformation and tumor progression. In melanoma it enhances viability and is an antigen for cytolytic T lymphocytes. MAGEA3/MAGE3 expression is limited to early developmental stages normally, but it is found expressed in many kinds of cancers including breast, lung, melanoma, and head and neck cancers. Because MAGEA3/MAGE3 can serve as a T cell antigen in melanoma, various research groups are using MAGEA3/MAGE3 in attempts to create vaccines and other immune treatments for melanoma, and work is underway to understand how to manage such treatments in patients with the disease. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-MAGEA3 Antibody/MAGE3 is an antibody against MAGEA3/MAGE3 for use in western blotting & IHC (Paraffin). 主要应用 - Western Blotting
应用说明 Western Blotting Analysis: A 1:5,000 dilution from a representative lot detected MAGEA3/MAGE3 in 10 µg of MDA-MB-231, MDA-MB-435, MCF10A, MDA-MB-468, T47D, and HCC1143 cell lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MAGEA3/MAGE3 in human breast cancer and human testis tissue.生物信息 免疫原品种 Blue carrier protein-conjugated linear peptide corresponding to human MAGEA3/MAGE3 near the C-terminus. 表位 Near C-terminus 浓缩 0.5 mg/mL 宿主 Rabbit 品种反应性 Human Species Reactivity Note Human. Immunogen is 73% identical in mouse and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005353
基因符号 - MAGE3
- MAGEA3
纯化方法 Affinity purified UniProt编号 - P43357
产品使用声明 质量保证 Evaluated by Western Blotting in MCF7 cell lysate.
Western Blotting Analysis: A 1:5,000 dilution of this antibody detected MAGEA3/MAGE3 in 10 µg of MCF7 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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