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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB9214 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-APH-1 Antibody 背景信息 The processing of the type 1 transmembrane protein beta-amyloid precursor protein (APP) by gamma secretase is thought to be a key event needed for the deposition of the beta-amyloid peptide in senile plaques found in Alzheimer's disease. The proteolytic activity of the gamma secretase cleaves the transmembrane domain of APP and releases the beta-amyloid peptide. Early or aberrant gamma-secretase cleavage of APP underlies the majority of early onset, familial Alzheimer's disease. {Guo, M et al (2003) Hum Mol Genet. 12(20):2669-78}. The gamma secretase consists of complex of four membrane associated proteins including presenilin, nicastrin, Aph-1 and Pen-2 {Gu, Y et al (2003) J Biol. Chem. 278(9):7374-7380; Kimberly, WT et al (2003) PNAS, USA 100(11):6382-6387}. It is believed that Aph-1 is a membrane protein that directly associates with presenilin and nicastrin within the gamma-secretase protein complex and stabilizes the presenilin within the complex, and allows the for proteolytic processing of presenilin and activation of the gamma-secretase activity{Takasugi, N et al (2003) Nature 422(6930):438-441}. 产品信息 格式 Serum 演示 Rabbit serum. Liquid containing no preservatives. 应用 应用 This Anti-APH-1 Antibody is validated for use in WB for the detection of APH-1. 主要应用 - Western Blotting
应用说明 Western blotting: 1:5,000-1:10,000. The antibody recognizes a protein of ~29 kDa on mouse brain tissue lysate.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from hAPH-1a 宿主 Rabbit 特异性 APH-1. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_016022.2
- NM_001077628.1
Entrez基因汇总 APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM] 基因符号 - Aph-1alpha
- APH1A
- UNQ579/PRO1141
- APH-1A
- APH-1a
- CGI-78
- 6530402N02Rik
UniProt编号 - Q96BI3
UniProt汇总 FUNCTION: SwissProt: Q96BI3 # Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
SIZE: 265 amino acids; 28996 Da
SUBUNIT: Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
TISSUE SPECIFICITY: Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
SIMILARITY: SwissProt: Q96BI3 ## Belongs to the APH-1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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