merck millipore,默克密理愽
  • merck millipore,默克密理博,373225,Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

  • merck millipore,默克密理博,373225,Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

    产品名称：Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem
    产品型号：373225
    The Hdm2 E3 Ligase Inhibitor, also referenced under CAS 414905-09-2, controls the biological activity of Hdm2 E3 Ligase. This small molecule/inhibitor is primarily used for Protease Inhibitors applica More>>

    merck millipore,默克密理博,373225,Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,373225,Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₀H₈F₆N₂O₃S414905-09-2
    描述
    概述 A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 > 100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
    产品目录编号 373225
    品牌系列 Calbiochem®
    同义词 N-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V
    参考
    参考 Lai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.
    产品信息
    CAS号 414905-09-2
    具有ATP竞争性 N
    形式 Pale yellow solid
    Hill配方 C₁₀H₈F₆N₂O₃S
    化学配方 C₁₀H₈F₆N₂O₃S
    Molar Mass 350.2
    可逆 Y
    结构配方图像
    生物信息
    主靶 ubiquitination of p53 in vitro
    主靶IC50 12.7 µM inhibiting ubiquitination of p53 in vitro using Ub-Ubc as the donor substrate
    纯度 ≥95% by NMR
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,373225,Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,07-369-I,Anti-dimethyl Histone H3 Antibody (Lys36)
下一件merck millipore产品：merck millipore,默克密理博,AB3708,Anti-Resistin Antibody


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