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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 AB763P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Collagen Type V Antibody 概述 Collagen Type V extracted and purified from human placenta. Antibody shows less than 0.1% reactivity with human Collagen Types I, III, and IV. AB763P also shows 0.1% reactivity with human Fibronectin and mouse Laminin by radioimmunoassay. 产品信息 格式 Purified 演示 IgG fraction. Liquid 应用 应用 Anti-Collagen Type V Antibody detects level of Collagen Type V & has been published & validated for use in ELISA, IF, RIA. 主要应用 - ELISA
应用说明 Immunohistochemistry: 1:40 dilution for immunofluorescent staining of frozen human skin, liver and placenta tissues.
Radio Immunoassay
ELISA
Optimal working dilution must be determined by end user.生物信息 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Human collagen type V: 100%
Human collagen type I, II, & III: < 0.5%
Human collagen type IV: 20%
Human fibronectin, albumin, immunoglobulins: < 0.5%.品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000093.3
Entrez基因汇总 This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. 基因符号 - OTTHUMP00000064637
- COL5A1
UniProt编号 - P20908
UniProt汇总 FUNCTION: SwissProt: P20908 # Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
SIZE: 1838 amino acids; 183560 Da
SUBUNIT: Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Sulfated on 40% of tyrosines.
DISEASE: SwissProt: P20908 # Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type I (EDS-I) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS-I is a connective-tissue disorder characterized by loose-jointedness and fragile, velvety, stretchable, bruisable skin that heals with peculiar 'cigarette-paper' scars. Inheritance is autosomal dominant. & Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type II (EDS-II) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis. Inheritance is autosomal dominant.
SIMILARITY: SwissProt: P20908 ## Belongs to the fibrillar collagen family. & Contains 1 laminin G-like domain. & Contains 1 TSP N-terminal (TSPN) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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