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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB6022 描述 Anti-beta Arrestin 2 Antibody Alternate Names - arrestin 4
- Cone arrestin
- Retinal cone arrestin-3
- arrestin 3, retinal (X-arrestin)
背景信息 The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001). 产品信息 格式 Affinity Purified 控制 - Fetal human brain tissue lysate
演示 Purified in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-beta Arrestin 2 Antibody is an antibody against beta Arrestin 2 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to an internal, near C-terminus, epitope of beta Arrestin 2. 表位 Near C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 The antibody recognizes human beta Arrestin 2 protein. 品种反应性 Human Species Reactivity Note Human. Predicted to react with ape and chimp based on sequence homology. Additional sequence homology (91%) is noted with mouse and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - P32121
基因符号 - cArr
- ARRX
- C-arrestin
- CAR
- X-arrestin
纯化方法 Antigen affinity purified UniProt编号 - P36575
UniProt汇总 FUNCTION: May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.
TISSUE SPECIFITY: Inner and outer segments, and the inner plexiform regions of the retina.
SEQUENCE SIMILARITIES: Belongs to the arrestin family.产品使用声明 质量保证 Evaluated on a representative lot by Western blot on fetal brain tissue lysate using Anti-beta Arrestin 2. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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