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品种反应性 主要应用 宿主 格式 抗体类型 B, H, M, R, Eq, Ca ICC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB6020 描述 Anti-MAP4 Antibody Alternate Names - MAP-4
- microtubule-associated protein 4
- cdc kinase
背景信息 Microtubule-associated protein 4 (MAP4) is a ubiquitous non-neuronal microtubule-associated protein. This protein binds, polymerizes, and stabilizes microtubules and is thought to regulate microtubule dynamics during the cell cycle. p34cdc2 kinase phosphorylation of MAP4 appears to regulate the control of microtubule reorganization at mitosis (Ookata, 1997). 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-MAP4 Antibody is validated for use in WB, IC for the detection of MAP4. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Western blot (SNAP ID) Analysis: 0.5 µg/mL from a previous lot detected MAP4 in 10 µg of HeLa cell lysate.
Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected MAP4 in HeLa, NIH/3T3, and A431 cells.生物信息 免疫原品种 KLH-conjugated peptide corresponding to the C-terminus of human MAP4. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Antibody recognizes the C-terminus of MAP4. 品种反应性 BovineHumanMouseRatHorseCanine Species Reactivity Note Demonstrated to react with human, mouse, and rat. Predicted to react with equine, canine, and bovine based upon 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002366
Entrez基因汇总 The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. 基因符号 - MAP-4
- MAP4
纯化方法 Protein A purfied UniProt编号 - P27816
UniProt汇总 FUNCTION: Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
SUBUNIT STRUCTURE: Interacts with SEPT2; this interaction impedes tubulin-binding.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.
SEQUENCE SIMILARITIES: Contains 4 Tau/MAP repeats.产品使用声明 质量保证 Evaluated by Western blot in HeLa cell lysate.
Western blot Analysis: 0.05 µg/mL of this antibody detected MAP4 in 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 50 µg
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