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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3888 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Dia1 Antibody Alternate Names - DIAPH1
- Dia1
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide as a preservative. 应用 应用 Anti-Dia1 Antibody is an antibody against Dia1 for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000-1:2,000 (0.5-1.0 μg/mL).
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to the N-terminus of human Diaphanous 1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Diaphanous 1 (Dia1, DIAPH1). Dia1 belongs to the Formin homology (FH) family of cytoskeletal organizer proteins. It interacts with Rho-GTP and profilin and promotes actin polymerization, cytokinesis, and stress fiber formation. Mutations in the human Diaphanous gene are linked with autosomal dominant deafness and premature ovarian failure. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005219.3
- NM_001079812.1
Entrez基因汇总 This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. 基因符号 - diaphanous-1
- DIAPH1
- LFHL1
- FLJ25265
- hDIA1
- DIAP1
- DFNA1
- DRF1
- hDia1
UniProt编号 - O60610
UniProt汇总 FUNCTION: SwissProt: O60610 # Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). In hearing it may play a role in the regulation of actin polymerization in hair cells.
SIZE: 1248 amino acids; 138979 Da
SUBUNIT: Homodimer. Interacts with the GTP-bound form of Rho. Interacts with RHOC, PFY1, MAPRE1, BAIAP2 and APC (By similarity).
TISSUE SPECIFICITY: Expressed in brain, heart, placenta, lung, kidney, pancreas, liver, skeletal muscle and cochlea.
DOMAIN: SwissProt: O60610 DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction (By similarity).
DISEASE: SwissProt: O60610 # Defects in DIAPH1 are the cause of non-syndromic sensorineural deafness autosomal dominant type 1 (DFNA1) [MIM:124900]. DFNA1 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
SIMILARITY: Belongs to the formin homology family. Diaphanous subfamily. & Contains 1 DAD (diaphanous autoregulatory) domain. & Contains 1 FH1 (formin homology 1) domain. & Contains 1 FH2 (formin homology 2) domain. & Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8ºC in undiluted aliquots for up to one year from date of receipt. 包装信息 数量 100 µg
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