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  • merck millipore,默克密理博,AB81023,Anti-Calpain II Antibody, large subunit

  • merck millipore,默克密理博,AB81023,Anti-Calpain II Antibody, large subunit

    产品名称：Anti-Calpain II Antibody, large subunit
    产品型号：AB81023
    Anti-Calpain II Antibody, large subunit is an antibody against Calpain II for use in WB.

    merck millipore,默克密理博,AB81023,Anti-Calpain II Antibody, large subunit

  • 产品介绍
  • merck millipore,默克密理博,AB81023,Anti-Calpain II Antibody, large subunit

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, R, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB81023
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Calpain II Antibody, large subunit
    Alternate Names
    • Calpain 2
    • M-Calpain
    背景信息 Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Calpain-1 and 2 consist of a common small subunit and a large variable subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF-hand domain IV.
    Type I calpain requires micromolar amounts of calcium, while type II calpain requires millimolar amounts of calcium.
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS pH 7.4 containing 0.02% sodium azide, 1% BSA and 50% glycerol as a stabilizer.
    应用
    应用 Anti-Calpain II Antibody, large subunit is an antibody against Calpain II for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1000 for colorimetric substrates or 1:5000 for chemiluminescent substrates (recommended starting concentration).

    Optimal working dilutions must be determined by the end user.
    生物信息
    表位 large subunit
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 The anti-calpain II antibody recognizes the 80 kDa and 58 kDa forms of Calpain II. It does not cross-react with other calpains.
    品种反应性 HumanRatMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001748.4
    Entrez基因汇总 The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported.
    基因符号
    • EC 3.4.22.53
    • CAPN2
    • millimolar-calpain
    • M-calpain
    • Millimolar-calpain
    • mCANP
    • FLJ39928
    • CANP2
    • CANPml
    • CANPL2
    UniProt编号
    • P17655
    UniProt汇总 FUNCTION: SwissProt: P17655 # Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
    COFACTOR: Binds 3 calcium ions.
    SIZE: 700 amino acids; 80009 Da
    SUBUNIT: Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
    SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.
    TISSUE SPECIFICITY: Ubiquitous.
    SIMILARITY: SwissProt: P17655 ## Belongs to the peptidase C2 family. & Contains 1 calpain catalytic domain. & Contains 3 EF-hand domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20*C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB81023,Anti-Calpain II Antibody, large subunit

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