merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5702,Anti-HES-1 Antibody

  • merck millipore,默克密理博,AB5702,Anti-HES-1 Antibody

    产品名称：Anti-HES-1 Antibody
    产品型号：AB5702
    This Anti-HES-1 Antibody is validated for use in IH, WB for the detection of HES-1.

    merck millipore,默克密理博,AB5702,Anti-HES-1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5702,Anti-HES-1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5702
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-HES-1 Antibody
    Alternate Names
    • Hairy 1
    背景信息 Hes1 is a transcriptional repressor of genes that require a bHLH protein for their transcription. It may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Hes1 is expressed in developing neuroectodermal and endodermal endocrine tissues, and Hes1 deficient embryos show severe defects in neuronal development, as well as pancreatic hypoplasia.
    产品信息
    格式 Affinity Purified
    控制
    • Human neural stem cells, Raji cell lysate.
    演示 Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.
    应用
    应用 This Anti-HES-1 Antibody is validated for use in IH, WB for the detection of HES-1.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western Blot:
    1:200-1:1,000 dilution using ECL.

    Immunohistochemistry:
    1:200-1:1,000 dilution of a previous lot worked.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide.
    宿主 Rabbit
    特异性 Recognizes HES-1 (Hairy family), a Helix-loop-helix class of transcription factor.
    品种反应性 MouseHuman
    Species Reactivity Note Human and rodent. Reactivity with other species has not been confirmed.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005524.2
    Entrez基因汇总 This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
    基因符号
    • HES-1
    • HES1
    • Hes1
    • HL
    • HHL
    • FLJ20408
    • HRY
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q14469
    UniProt汇总 FUNCTION: SwissProt: Q14469 # Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity).
    SIZE: 280 amino acids; 29541 Da
    SUBUNIT: Transcription repression requires formation of a complex with a corepressor protein (Groucho) such as TLE2 (By similarity). Interacts with SIRT1.
    SUBCELLULAR LOCATION: Nucleus.
    DOMAIN: SwissProt: Q14469 Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG). & The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.
    SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 Orange domain. ... hide » see more »
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -80ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB5702,Anti-HES-1 Antibody

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