merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5684,Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3.

  • merck millipore,默克密理博,AB5684,Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3.

    产品名称：Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3.
    产品型号：AB5684
    Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3. detects level of Neurogenin-3 & has been published & validated for use in IH.

    merck millipore,默克密理博,AB5684,Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3.

  • 产品介绍
  • merck millipore,默克密理博,AB5684,Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3.

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MIHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5684
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3.
    Alternate Names
    • MATH4b
    背景信息 Neurogenins are a family of bHLH transcription factors involved in specifying neuronal differentiation. They are related to Drosophila atonal. The neurogenins (ngns) make up one of these atonal-related gene families. In neural crest cells, the atonal-related neurogenin family is particularly important for the sensory lineage (Neurogenins Are Essential for the Formation of dorsal root ganglia), while the achaete-scute homologue ash1 (Mash1) is important for aspects of autonomic neurogenesis (Mash1 Is Essential for Noradrenergic Differentiation). Neurogenin-3 promotes pancreatic development.
    产品信息
    格式 Affinity Purified
    控制
    • Rat brain tissue.
    演示 Affinity purified immunoglobulin. Precipitated antibody in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.
    应用
    应用 Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3. detects level of Neurogenin-3 & has been published & validated for use in IH.
    主要应用
    • Immunohistochemistry
    应用说明 Immunohistochemistry: 1:200-1:1,000.
    Immunocytochemistry: Cat. # AB5684 detects Neurogenin-3 in PC12 cells at 1:500 dilution.
    Not recommended for Western blot
    生物信息
    免疫原品种 Synthetic peptide, amino acids 80-93 of mouse Neurogenin 3.
    表位 a.a. 80-93 of mouse Neurogenin 3.
    宿主 Rabbit
    特异性 Recognizes Neurogenin 3 (MATH4b), a Helix-loop-helix class of transcription factor.
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_020999.2
    Entrez基因汇总 Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm (Gradwohl et al., 2000 [PubMed 10677506]).[supplied by OMIM]
    基因符号
    • Neurogenin-3
    • NEUROG3
    • ATOH5
    • Atoh5
    • ngn3
    • NGN3
    • MATH4B
    • Math4B
    UniProt编号
    • Q9Y4Z2
    UniProt汇总 FUNCTION: SwissProt: Q9Y4Z2 # Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).
    SIZE: 214 amino acids; 22969 Da
    SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein (By similarity).
    SUBCELLULAR LOCATION: Nucleus (Potential).
    DISEASE: SwissProt: Q9Y4Z2 # Defects in NEUROG3 are the cause of congenital malabsorptive diarrhea 4 (DIAR4) [MIM:610370]. DIAR4 is an autosomal recessive disorder characterized by generalized malabsorption and a paucity of enteroendocrine cells. Patients with congenital diarrhea generally present within the first weeks after birth with severe, life-threatening watery diarrhea that can be classified as either secretory or malabsorptive in nature. Routine clinical evaluation, including intestinal biopsy, may be used to further categorize the diarrhea according to the severity of the inflammation and to assess the integrity of the crypt- villus axis and the architecture of the epithelial layer. On the basis of both clinical and pathological characteristics, various specialized formulas may be used to minimize the diarrheal symptoms, although some children require extended periods of intravenous nutrition to sustain normal growth and development.
    SIMILARITY: SwissProt: Q9Y4Z2 ## Contains 1 basic helix-loop-helix (bHLH) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB5684,Anti-Neurogenin-3 Antibody, a.a. 80-93 of mouse Neurogenin-3.

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