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  • merck millipore,默克密理博,AB5390-50UL,Anti-Sodium Channel Nav1.7 Antibody, Pain

  • merck millipore,默克密理博,AB5390-50UL,Anti-Sodium Channel Nav1.7 Antibody, Pain

    产品名称：Anti-Sodium Channel Nav1.7 Antibody, Pain
    产品型号：AB5390-50UL
    Detect Sodium Channel Nav1.7 using this Anti-Sodium Channel Nav1.7 Antibody, Pain validated for use in IH & WB.

    merck millipore,默克密理博,AB5390-50UL,Anti-Sodium Channel Nav1.7 Antibody, Pain

  • 产品介绍
  • merck millipore,默克密理博,AB5390-50UL,Anti-Sodium Channel Nav1.7 Antibody, Pain

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWB, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5390-50UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Sodium Channel Nav1.7 Antibody, Pain
    Alternate Names
    • PN1
    • NENA
    • NE
    • SCN9A
    产品信息
    格式 Affinity Purified
    控制
    • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
    演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
    应用
    应用 Detect Sodium Channel Nav1.7 using this Anti-Sodium Channel Nav1.7 Antibody, Pain validated for use in IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western blot: 1:200 using ECL on rat brain membranes.

    Immunohistochemistry on rat dorsal root ganglion (DRG) frozen sections.

    Dilutions should be made using a carrier protein such as BSA (1-3%)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Purified peptide from rat Nav1.7 (amino acids 446-460) (Accession AAB50403).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Nav1.7 protein (PN1, NENA, NE, Type IX Voltage Gated Sodium Channel, Scn9a). The epitope is specific for Nav1.7 and is not present in any other known protein.

    SPECIES REACTIVITIES: The immunogen sequence is highly conserved in rabbit and human (14/15 and 13/15 respectively). Other species have not been tested.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002977.2
    基因符号
    • PN1
    • SCN9A
    • NE-NA
    • NENA
    • ETHA
    • Nav1.7
    • hNE-Na
    UniProt编号
    • Q15858
    UniProt汇总 FUNCTION: SwissProt: Q15858 # Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).
    SIZE: 1988 amino acids; 226342 Da
    SUBUNIT: The sodium channel consists of a large polypeptide and 2- 3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4 and NEDD4L (By similarity).
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=In neurite terminals (By similarity).
    TISSUE SPECIFICITY: Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system while isoform 2 is expressed preferentially in the dorsal root ganglion.
    DOMAIN: SwissProt: Q15858 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
    PTM: Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4 (By similarity).
    DISEASE: SwissProt: Q15858 # Defects in SCN9A are the cause of primary erythermalgia [MIM:133020]. It is an autosomal dominant disease characterized by recurrent episodes of severe pain associated with redness and warmth in the feet or hands. & Defects in SCN9A are the cause of autosomal recessive congenital indifference to pain [MIM:243000]; also known as channelopathy-associated insensitivity to pain. Affected individuals have a congenital inability to perceive any form of pain, in any part of the body. All other sensory modalities are preserved and the peripheral and central nervous systems are apparently intact. Patients perceive the sensations of touch, warm and cold temperature, proprioception, tickle and pressure, but not painful stimuli. There is no evidence of a motor or sensory neuropathy, either axonal or demyelinating. & Defects in SCN9A are a cause of paroxysmal extreme pain disorder (PEPD) [MIM:167400]; previously known as familial rectal pain (FRP). PEPD is an autosomal dominant paroxysmal disorder of pain and autonomic dysfunction. The distinctive features are paroxysmal episodes of burning pain in the rectal, ocular, and mandibular areas accompanied by autonomic manifestations such as skin flushing.
    SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5390-50UL,Anti-Sodium Channel Nav1.7 Antibody, Pain

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