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merck millipore,默克密理博,341310,FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem
产品名称：FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem
产品型号：341310
The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.
merck millipore,默克密理博,341310,FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₃₁H₂₆N₂O₃ 300657-03-8 描述 概述 A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo. 产品目录编号 341310 品牌系列 Calbiochem®
同义词 adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403 参考 参考 Furuhashi, M., et al. 2007. Nature 447, 959.
Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.产品信息 CAS号 300657-03-8 形式 White solid Hill配方 C₃₁H₂₆N₂O₃ 化学配方 C₃₁H₂₆N₂O₃ Molar Mass 474.6 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO, MeOH, or EtOH 安全信息 S相 S: 22-24/25-36-45
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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