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merck millipore,默克密理博,AB5372,Anti-Trk B Antibody, pain, a.a. 54-67 rTrkB
产品名称：Anti-Trk B Antibody, pain, a.a. 54-67 rTrkB
产品型号：AB5372
Anti-Trk B Antibody, pain, a.a. 54-67 rTrkB detects level of Trk B & has been published & validated for use in IH & WB.
merck millipore,默克密理博,AB5372,Anti-Trk B Antibody, pain, a.a. 54-67 rTrkB
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB, IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB5372 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Trk B Antibody, pain, a.a. 54-67 rTrkB Alternate Names - Tyrosine Kinase Receptor B
- BDNF/NT-3 Growth Factors Receptor
产品信息 格式 Serum 演示 Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue. 应用 应用 Anti-Trk B Antibody, pain, a.a. 54-67 rTrkB detects level of Trk B & has been published & validated for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry: 1:2,000-1:3,000. The antibody reacts well with tissue from the rat spinal cord.
Immunoblotting: 1:1,000-1:1,500 on rat membrane preparations. The antibody should be
evaluated for use in Western blot by the end user. Its utility will be dependant on the level of
the protein expressed in the tissues or cells being tested.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 A synthetic peptide from rat trkB 表位 a.a. 54-67 rtrkB 宿主 Rabbit 特异性 TrkB. The sequence used for the immunogen was chosen to avoid cross reactivity with trkA or trkC. 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006180.3
- NM_001007097.1
- NM_001018064.1
- NM_001018065.1
- NM_001018066.1
Entrez基因汇总 This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. 基因符号 - EC 2.7.10.1
- NTRK2
- Trk-B
- GP145-TrkB
- TRKB
UniProt编号 - Q16620
UniProt汇总 FUNCTION: SwissProt: Q16620 # Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC- gamma-1.
SIZE: 822 amino acids; 91999 Da
SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.
PTM: Ligand-mediated auto-phosphorylation.
SIMILARITY: SwissProt: Q16620 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C to -70°C for up to 6 months after date of receipt. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
上一件merck millipore产品：merck millipore,默克密理博,9290-OP,OmniPur TRIS Solution 1.0M pH 8.0 - Calbiochem
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