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品种反应性 主要应用 宿主 格式 抗体类型 B, H, M, R, Chp, Rhesus Macaque, Eq, Po ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2301 描述 Anti-Calnexin Antibody Alternate Names - p90
- Major histocompatibility complex class I antigen-binding protein p88
- IP90
- Calnexin
背景信息 Calnexin is a Ca++ binding protein found in ER transmembranes that binds to specific n-linked oligosaccharides found on newly synthesized proteins. Calnexin associates with the ER membrane phosphoglycoprotein, signal sequence receptor SSRμ, and has been identified as the ER protein associated with major histocompatibility complex (MHC) class I heavy chain and with the T-cell receptor and membrane immunoglobulin before assembly of these multimeric complexes. Hence, calnexin may represent a molecular chaperone in the ER membrane that is selective for incompletely folded oligomeric membrane proteins newly translocated to the ER. 产品信息 格式 Affinity Purified 控制 - Human brain tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Calnexin Antibody is an antibody against Calnexin for use in WB, IC, IH(P). 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Calnexin in NIH/3T3 cells.
Immunohistochemistry Analysis: A 1:1,000-2,000 dilution from a representative lot detected Calnexin in human brain and human prostate tissues.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human Calnexin. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Calnexin at the C-terminus. 品种反应性 BovineHumanMouseRatChimpanzeeRhesus MacaqueHorsePig Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Chimpanzee, Rhesus Macaque, Equine, Porcine, and Bovine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001737
Entrez基因汇总 This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]. 基因符号 - CANX
纯化方法 Affinity purified UniProt编号 - P27824
UniProt汇总 FUNCTION: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SEQUENCE SIMILARITIES: Belongs to the calreticulin family.产品使用声明 质量保证 Evaluated by Western Blot in human brain tissue lysate.
Western Blot Analysis: A 1:10,000 dilution of this antibody detected Calnexin on 10 µg of human brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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