merck millipore,默克密理愽
  • merck millipore,默克密理博,AB4251,Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular

  • merck millipore,默克密理博,AB4251,Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular

    产品名称：Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular
    产品型号：AB4251
    This Anti-CXC Chemokine Receptor 4 Antibody, N-terminal, extracellular is validated for use in IH(P) for the detection of CXC Chemokine Receptor 4.

    merck millipore,默克密理博,AB4251,Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular

  • 产品介绍
  • merck millipore,默克密理博,AB4251,Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIH(P)RbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB4251
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular
    Alternate Names
    • CXCR4
    背景信息 CXCR4 is a chemokine receptor involved in organ vascularization, neuronal cell migration, and patterning of the central nervous system during development. It binds stromal cell-derived factor 1 (SDF1) and mediates migration of resting leukocytes and is unique in homing hematopoietic progenitors to bone marrow. These properties suggest that CXCR4 is involved in tumor cell migration and local tumor invasion. It is also an HIV-1 fusion co-factor that allows HIV-1 invasion in diverse human cell types. CXCR4 has two isoforms that are produced by alternative splicing and has been reported to be expressed in cells of the immune and central nervous systems. It is highly expressed in brain and heart, and in white blood cells, vascular endothelial cells, and umbilical cord endothelial cells. In brain tumors, CXCR4 is expressed in regions of angiogenesis and degenerative, necrotic, and microcystic changes (Rempel et al., 2000). ESTs have been isolated from a wide variety of tissue libraries, particularly uterus, kidney, lung, tonsil, and brain.
    产品信息
    格式 Affinity Purified
    演示 Peptide-affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide
    应用
    应用 This Anti-CXC Chemokine Receptor 4 Antibody, N-terminal, extracellular is validated for use in IH(P) for the detection of CXC Chemokine Receptor 4.
    主要应用
    • Immunohistochemistry (Paraffin)
    应用说明 Immunohistochemistry (formalin-fixed paraffin-embedded tissues)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to a sequence within the N-terminal extracellular domain of human CXCR4. The immunogen has 93% homology with mouse and rat.
    表位 N-terminal, extracellular
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes human CXCR4. The specificity of this antibody has been confirmed by IHC staining of cardiac myocytes in human heart.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003467.2
    • NM_001008540.1
    Entrez基因汇总 This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    基因符号
    • CXCR-4
    • LCR1
    • NPYR
    • HM89
    • fusin
    • HSY3RR
    • CXC-R4
    • NPYY3
    • NPYRL
    • CD184
    • D2S201E
    • LESTR
    • CXCR4
    • WHIM
    • NPY3R
    • NPYY3R
    • FB22
    • LAP3
    • Fusin
    UniProt编号
    • P61073
    UniProt汇总 FUNCTION: SwissProt: P61073 # Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
    SIZE: 352 amino acids; 39746 Da
    SUBUNIT: Interacts with HIV-1 surface protein gp120 and Tat.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.
    DOMAIN: SwissProt: P61073 The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity.
    PTM: Sulfated.
    DISEASE: SwissProt: P61073 # Defects in CXCR4 are a cause of WHIM syndrome [MIM:193670]; also called warts, hypogammaglobulinemia, infections, and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis.
    SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB4251,Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular

上一件merck millipore产品：merck millipore,默克密理博,3050-OP,OmniPur CHAPS - CAS 75621-03-3 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,437650,Lipopolysaccharide, Salmonella typhimurium - Calbiochem


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