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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB4227 Replaces MABE517 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Pax5 Antibody 产品信息 格式 Affinity Purified 演示 Peptide affinity purified antibody. Liquid in 0.02M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide as a preservative. 应用 应用 Anti-Pax5 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of Pax5 & has been validated in WB. 主要应用 - Western Blotting
应用说明 Western blot: 2-5 μg/mL
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to an N-terminal sequence of human Pax5. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Pax5. 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_016734.1
Entrez基因汇总 This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. 基因符号 - BSAP
- PAX5
UniProt编号 - Q02548
UniProt汇总 FUNCTION: SwissProt: Q02548 # May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
SIZE: 391 amino acids; 42149 Da
SUBUNIT: Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4.
SUBCELLULAR LOCATION: Nucleus.
DEVELOPMENTAL STAGE: Expressed at early B-cell differentiation, in the developing CNS and in adult testis.
PTM: O-glycosylated (Probable).
DISEASE:SwissProt: Q02548 # A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.
SIMILARITY: SwissProt: Q02548 ## Contains 1 paired domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8ºC in undiluted aliquots for up to one year from date of receipt. 包装信息 数量 200 µg
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下一件merck millipore产品：merck millipore,默克密理博,AB1120F,Anti-Chlamydia trachomatis-EB Antibody, FITC-conjugated
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