merck millipore,默克密理愽
  • merck millipore,默克密理博,05-901R,Anti-NR2A Antibody, clone A12W, rabbit monoclonal

  • merck millipore,默克密理博,05-901R,Anti-NR2A Antibody, clone A12W, rabbit monoclonal

    产品名称：Anti-NR2A Antibody, clone A12W, rabbit monoclonal
    产品型号：05-901R
    This Anti-NR2A Antibody, clone A12W is validated for use in WB for the detection of NR2A.

    merck millipore,默克密理博,05-901R,Anti-NR2A Antibody, clone A12W, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,05-901R,Anti-NR2A Antibody, clone A12W, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, R, HWBRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-901R
    描述 Anti-NR2A Antibody, clone A12W, rabbit monoclonal
    Alternate Names
    • glutamate receptor, ionotropic, N-methyl D-aspartate 2A
    • N-methyl D-aspartate receptor subtype 2A
    • N-methyl-D-aspartate receptor channel, subunit epsilon-1
    • N-methyl-D-aspartate receptor subunit 2A
    • NMDA receptor subtype 2A
    背景信息 NR2 or glutamate receptor, ionotropic, N-methyl D-aspartate 2 (NMDA2; NMDAR2) along with the NR1 subunit forms a heterodimer that make up the NMDA receptor. By alternative splicing there are various isoforms of NR2 classified as NR2A through D. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. The NR1 subunit binds glycine while the NR2 subunit binds glutamine for activation. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory.
    产品信息
    格式 Purified
    控制
    • Rat brain microsomal tissue lysate
    演示 Purified rabbit monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide and 40% Glycerol.
    应用
    应用 This Anti-NR2A Antibody, clone A12W is validated for use in WB for the detection of NR2A.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Histidine-tagged recombinant protein corresponding to the C-terminus of mouse NR2A.
    表位 C-terminus
    克隆 clone A12W
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes NR2A at the C-terminus.
    同种型 IgG
    品种反应性 MouseRatHuman
    Species Reactivity Note Demonstrated to react with rat. Predicted to react with mouse based on immunogen design. Predicted to react with human based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_032196
    基因符号
    • NR2A
    • GRIN2A
    • hNR2A
    • Glutamate
    • NMDAR2A
    纯化方法 Protein A
    UniProt编号
    • P35436
    UniProt汇总 FUNCTION: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

    SUBUNIT STRUCTURE: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4 (By similarity). Interacts with HIP1 and NETO1. Interacts with LRFN2 (By similarity).

    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein

    SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2A/GRIN2A subfamily. [View classification]
    产品使用声明
    质量保证 Evaluated by Western Blot in rat brain microsomal tissue lysate.

    Western Blot Analysis: 1:3000 dilution of this antibody detected NR2A on 10 µg of rat brain microsomal tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,05-901R,Anti-NR2A Antibody, clone A12W, rabbit monoclonal

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