- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB3890 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-DAP12 Antibody 背景信息 Natural killer (NK) cells are lymphocytes that function as a component of innate immunity against intracellular and parasitic pathogens, and possibly tumors. DAP12 is expressed on the surface of NK cells as a disulfide-linked homodimer and contains an immunoreceptor tyrosine based activation motif (ITAM) in its cytoplasmic domain. DAP12 non-covalently associates with members of the killer cell immunoglobulin-like receptor (KIR) family resulting in cellular activation. 产品信息 格式 Purified 控制 - Western blot positive control: U937 cell line
演示 Protein A purified immunoglobulin. Liquid in 0.02M Phosphate Buffer, 0.25M NaCl, with 0.1% sodium azide. 应用 应用 Anti-DAP12 Antibody is an antibody against DAP12 for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1.0 μg/mL
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acid residues 89-113 of human DAP12 (Accession # AAD09437). 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes human DAP12. This antibody detects a band of approximately 12 kDa in Western blot analysis of U937 cell lysate. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_198125.1
- NM_003332.2
Entrez基因汇总 This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined. 基因符号 - PLOSL
- TYROBP
- DAP12
- PLO-SL
- KARAP
UniProt编号 - O43914
UniProt汇总 FUNCTION: SwissProt: O43914 # Non-covalently associates with membrane glycoproteins of the killer-cell inhibitory receptor (KIR) family without an ITIM in their cytoplasmic domain. Cross-linking of KIR-TYROBP complexes results in cellular activation.
SIZE: 113 amino acids; 12179 Da
SUBUNIT: Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with CLECSF5. Interacts with SIGLEC14.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.
PTM: Tyrosine phosphorylated.
DISEASE: "SwissProt: O43914 # Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns."
SIMILARITY: SwissProt: O43914 ## Belongs to the TYROBP family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C for up to 12 months from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,111685,淀粉
下一件merck millipore产品：merck millipore,默克密理博,565785,β-Secretase Activity Assay Kit, Fluorogenic
相关产品
merck millipore,默克密理博,HTS223RTA,Ready-to-Assay™ D4 Dopamine Receptor Frozen Cells
merck millipore,默克密理博,475938,MT2-MMP, Catalytic Domain, Human, Recombinant, E. coli
merck millipore,默克密理博,SF-165,HRAS; Human, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,PC138,Anti-NF-κB (p65, RelA) (Ab-2) Rabbit pAb
merck millipore,默克密理博,111685,淀粉
merck millipore,默克密理博,565785,β-Secretase Activity Assay Kit, Fluorogenic
merck millipore,默克密理博,14-691M,MRCKα Protein, active, 250 µg
merck millipore,默克密理博,CBL496,Anti-CD34 Class II Antibody, clone QBEND/10
merck millipore,默克密理博,AB15708B,Anti-Beta III Tubulin, Biotin conjugate Antibody
merck millipore,默克密理博,HTS241RTA,Ready-to-Assay™ SUCNR1 / GPR91 Succinate Receptor Frozen Cells