merck millipore,默克密理愽
  • merck millipore,默克密理博,14-691M,MRCKα Protein, active, 250 µg

  • merck millipore,默克密理博,14-691M,MRCKα Protein, active, 250 µg

    产品名称：MRCKα Protein, active, 250 µg
    产品型号：14-691M
    Active, C-terminal 6His-tagged, recombinant, human MRCKα, amino acids 1-473. For use in Kinase Assays.

    merck millipore,默克密理博,14-691M,MRCKα Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-691M,MRCKα Protein, active, 250 µg

    描述
    产品目录编号 14-691M
    品牌系列 Upstate
    商名
    • Upstate
    描述 MRCKα Protein, active, 250 µg
    概述 C-terminal 6His-tagged, recombinant, human MRCKα, amino acids 1-473.
    应用
    应用 Active, C-terminal 6His-tagged, recombinant, human MRCKα, amino acids 1-473. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 MRCKα, amino acids 1-473, expressed by baculovirus in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_014826.4
    • NM_003607.3
    Entrez基因汇总 The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.
    基因符号
    • MRCKA
    • CDC42BPA
    • DKFZp686L1738
    • PK428
    • DKFZp686P1738
    • KIAA0451
    • FLJ23347
    • MRCK
    蛋白靶 MRCKα
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • Q5VT25
    UniProt汇总 FUNCTION: SwissProt: Q5VT25 # May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.
    COFACTOR: Magnesium.
    SIZE: 1732 amino acids; 197307 Da
    SUBUNIT: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42.
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity).
    TISSUE SPECIFICITY: Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
    SIMILARITY: SwissProt: Q5VT25 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 CNH domain. & Contains 1 CRIB domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of S6 Kinase/Rsk2 Substrate Peptide 2 (KKRNRTLTV)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C from date of shipment
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-691) and in bulk (cat# 14-691-K).

    merck millipore,默克密理博,14-691M,MRCKα Protein, active, 250 µg

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