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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB, ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 AB3876 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-SUMO2/3 Antibody Alternate Names - Sentrin
- Small Ubiquitin-like Modifier
产品信息 格式 Purified 演示 Immunoglobulin was purified by protein G affinity chromatography and is presented as a liquid in PBS with 0.09% sodium azide. 应用 应用 This Anti-SUMO2/3 Antibody is validated for use in ELISA, WB for the detection of SUMO2/3. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1:500 (11kDa)
ELISA: 1:1,000
Immunohistochemistry: 1:50-100
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acid residues 50-100 of human SUMO2/3. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes human SUMO2/3 (small ubiquitin-like modifier), also known as Sentrin. SUMO has been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS, and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. These bindings implicate SUMO in the stabilization of the target proteins and/or their localization to subcellular complexes. 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006936.2
Entrez基因汇总 SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).[supplied by OMIM] 基因符号 - SUMO-2
- SUMO3
- SMT3H1
- SMT3A
- SUMO-3
UniProt编号 - P55854
UniProt汇总 FUNCTION: SwissProt: P55854 # Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.
SIZE: 103 amino acids; 11637 Da
SUBUNIT: Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins (By similarity).
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed predominantly in liver.
PTM: Polymeric chains can be formed through Lys-11 cross-linking. & Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.
SIMILARITY: SwissProt: P55854 ## Belongs to the ubiquitin family. SUMO subfamily. & Contains 1 ubiquitin-like domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20ºC in undiluted aliquots for up to one year from date of receipt. 包装信息 数量 100 µg
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