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merck millipore,默克密理博,09-817,Anti-JMJD1C Antibody
产品名称：Anti-JMJD1C Antibody
产品型号：09-817
Use Anti-JMJD1C Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect JMJD1C also known as jumonji domain containing 1C or TR-interacting protein 8.
merck millipore,默克密理博,09-817,Anti-JMJD1C Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rhesus Macaque, H, Rb, Chp ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-817 描述 Anti-JMJD1C Antibody Alternate Names - Jumonji domain-containing protein 1C
- JMJD
- jumonji domain containing 1C
- TR-interacting protein 8
- thyroid receptor interacting protein 8
- probable JmjC domain-containing histone demethylation protein 2C
- thyroid hormone receptor interactor 8
- Thyroid receptor-interacting protein 8
背景信息 JMJD1C (jumonji domain-containing protein 1C) is also known as TRIP8 and mutations in this histone demethylase have been linked to certain forms of autism. JMJD1C is also thought to work in reactivating genes in embryonic stem cells, pancreatic islet and gastric cancer. JMJD1C has also been implicated as a gene expression regulator. JMJD1C with WHISTLE have recently been shown to also play a role in mouse testis development. JMJD1C has been identified as a nuclear-receptor coactivator and is a candidate gene for autism. 产品信息 格式 Affinity Purified 控制 - HeLa nuclear extract
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-JMJD1C Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect JMJD1C also known as jumonji domain containing 1C or TR-interacting protein 8. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected JMJD1C in HeLa cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human JMJD1C. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Rhesus MacaqueHumanRabbitChimpanzee Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rabbit, Chimpanzee, Rhesus Macaque, and Orangutan based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_116165
基因符号 - JHDM2C
- TRIP8
- RP11-10C13.2
- JMJD1C
纯化方法 Affinity purified UniProt编号 - Q15652
UniProt汇总 FUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).
COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).
SUBUNIT STRUCTURE: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.
SUBCELLULAR LOCATION: Nucleus (By similarity).
DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.
Contains 1 JmjC domain.
SEQUENCE CAUTION: The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171.
The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697.
The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction.产品使用声明 质量保证 Evaluated by Western Blot in HeLa nuclear extract.
Western Blot Analysis: 1 µg/mL of this antibody detected JMJD1C on 10 µg of HeLa nuclear extract.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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