merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3865,Anti-CaMKII Antibody, phospho-specific (Thr305)

  • merck millipore,默克密理博,AB3865,Anti-CaMKII Antibody, phospho-specific (Thr305)

    产品名称：Anti-CaMKII Antibody, phospho-specific (Thr305)
    产品型号：AB3865
    Detect CaMKII using this Anti-CaMKII Antibody, phospho-specific (Thr305) validated for use in WB.

    merck millipore,默克密理博,AB3865,Anti-CaMKII Antibody, phospho-specific (Thr305)

  • 产品介绍
  • merck millipore,默克密理博,AB3865,Anti-CaMKII Antibody, phospho-specific (Thr305)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, Dr, H, MWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB3865
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-CaMKII Antibody, phospho-specific (Thr305)
    产品信息
    格式 Serum
    演示 Neat serum.
    应用
    应用 Detect CaMKII using this Anti-CaMKII Antibody, phospho-specific (Thr305) validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1000

    Dot blots: 1:1000

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Thr305 of CaMKII. Sequence is identical in human, mouse, rat, bovine, chicken, Drosophila, and Limulus and in alpha, beta, and delta isoforms.
    表位 phospho-specific (Thr305)
    宿主 Rabbit
    特异性 Recognizes the alpha, beta and gamma isoforms of CaMKII (Ca2+/calmodulin-dependent protein kinase II) when phosphorylated at Thr305. CaMKII is a prominent serine/threonine kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
    品种反应性 RatDrosophilaHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_171825.1
    • NM_015981.2
    Entrez基因汇总 The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
    基因符号
    • EC 2.7.11.17
    • CAMK2A
    • KIAA0968
    • CAMKA
    修改
    • Phosphorylation
    UniProt编号
    • Q9UQM7
    UniProt汇总 FUNCTION: SwissProt: Q9UQM7 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
    SIZE: 478 amino acids; 54030 Da
    SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1 and SYNGAP1 (By similarity).
    SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).
    SIMILARITY: SwissProt: Q9UQM7 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20ºC for up to one year from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB3865,Anti-CaMKII Antibody, phospho-specific (Thr305)

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