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merck millipore,默克密理博,324515,eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem
产品名称：eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem
产品型号：324515
The eEF-2 Kinase Inhibitor, NH125, also referenced under CAS 278603-08-0, controls the biological activity of eEF-2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephos More>>
merck millipore,默克密理博,324515,eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₇H₄₅IN₂ 278603-08-0 描述 概述 A cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC50 = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC50 = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent. 产品目录编号 324515 品牌系列 Calbiochem®
同义词 1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125 参考 参考 Arora, S., et al. 2004. Mol. Pharmacol. 66, 460.
Arora, S., et al. 2003. Cancer Res. 63, 6894.
Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.产品信息 CAS号 278603-08-0 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₂₇H₄₅IN₂ 化学配方 C₂₇H₄₅IN₂ Molar Mass 524.6 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 Bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII 主靶IC50 60 nM against the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII 纯度 ≥95% by NMR 理化信息 细胞可渗透 Y 溶解度 DMSO or 70% EtOH 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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