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merck millipore,默克密理博,AB3532P,Anti-Epithelial Sodium Channel-β Antibody
产品名称：Anti-Epithelial Sodium Channel-β Antibody
产品型号：AB3532P
This Anti-Epithelial Sodium Channel-β Antibody is validated for use in ELISA, WB for the detection of Epithelial Sodium Channel-β.
merck millipore,默克密理博,AB3532P,Anti-Epithelial Sodium Channel-β Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3532P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Epithelial Sodium Channel-β Antibody Alternate Names - ENaC-beta
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin in PBS containing 0.1% BSA. 应用 应用 This Anti-Epithelial Sodium Channel-β Antibody is validated for use in ELISA, WB for the detection of Epithelial Sodium Channel-β. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-10 μg/mL using ECL. 83-90kDa bands, membrane preparations are recommended (Masilamani et al., 1999).
ELISA: 0.5-1.0 mg/mL using 1 mg/mL control peptide to coat plate.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A 20 amino acid peptide sequence near the N-terminus of rat ENaC beta. The immunogen sequence is 100% conserved in mouse, 94% in rabbit, 81% in human, 76% in ovine and 64% in xenopus. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes rat Epithelial Sodium Channel beta (ENaC beta). The immunogen shows no significant sequence homology with other ENaC subunits. 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000336.2
基因符号 - Beta-NaCH
- SCNN1B
- ENaCb
- Beta-ENaC
- ENaCbeta
- SCNEB
- ENaCB
UniProt编号 - P51168
UniProt汇总 FUNCTION: SwissProt: P51168 # Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
SIZE: 640 amino acids; 72659 Da
SUBUNIT: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells.
PTM: Phosphorylated on serine and threonine residues (By similarity).
DISEASE: SwissProt: P51168 # Defects in SCNN1B are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss. & Defects in SCNN1B are a cause of Liddle syndrome [MIM:177200]. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.
SIMILARITY: SwissProt: P51168 ## Belongs to the amiloride-sensitive sodium channel family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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