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  • merck millipore,默克密理博,AB3530P,Anti-Epithelial Sodium Channel-α Antibody

  • merck millipore,默克密理博,AB3530P,Anti-Epithelial Sodium Channel-α Antibody

    产品名称：Anti-Epithelial Sodium Channel-α Antibody
    产品型号：AB3530P
    Anti-Epithelial Sodium Channel-α Antibody is an antibody against Epithelial Sodium Channel-α for use in WB.

    merck millipore,默克密理博,AB3530P,Anti-Epithelial Sodium Channel-α Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB3530P,Anti-Epithelial Sodium Channel-α Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3530P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Epithelial Sodium Channel-α Antibody
    Alternate Names
    • ENaC-alpha
    产品信息
    格式 Affinity Purified
    控制
    • Epithelial structures
    演示 Affinity Purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA and 0.1% sodium azide.
    应用
    应用 Anti-Epithelial Sodium Channel-α Antibody is an antibody against Epithelial Sodium Channel-α for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1-10 μg/mL using ECL and rat brain membrane preparations, see membrane preparation protocol under Technical Support\\General Technical Info\\General Methods.

    83-90kDa band is expected.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 A 20 amino acid peptide sequence near the N-terminus of rat ENaC alpha (Linguela et al. 1993; Canessa et al.

    1993; Snyder et al. 1994; Waldmann et al. 1995; Kreutz et al. 1997; Voilley et al.

    1994; McDonald et al. 1994; Ludwig et al. 1998; Garty & Palmer 1997).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes rat Epithelial Sodium Channel alpha (ENaC alpha). The immunogen shows no significant sequence homology with other ENaC subunits.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001038.4
    基因符号
    • ENaCalpha
    • SCNN1A
    • SCNEA
    • FLJ21883
    • ENaCa
    • SCNN1
    • Alpha-ENaC
    • Alpha-NaCH
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P37088
    UniProt汇总 FUNCTION: SwissProt: P37088 # Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
    SIZE: 669 amino acids; 75704 Da
    SUBUNIT: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.
    SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells.
    TISSUE SPECIFICITY: Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart.
    PTM: Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation (By similarity).
    DISEASE: SwissProt: P37088 # Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss.
    SIMILARITY: SwissProt: P37088 ## Belongs to the amiloride-sensitive sodium channel family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB3530P,Anti-Epithelial Sodium Channel-α Antibody

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