merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3077,Anti-Aquaporin 8 Antibody, colon & pancreas only

  • merck millipore,默克密理博,AB3077,Anti-Aquaporin 8 Antibody, colon & pancreas only

    产品名称：Anti-Aquaporin 8 Antibody, colon & pancreas only
    产品型号：AB3077
    This Anti-Aquaporin 8 Antibody, colon & pancreas only is validated for use in ELISA, WB for the detection of Aquaporin 8.

    merck millipore,默克密理博,AB3077,Anti-Aquaporin 8 Antibody, colon & pancreas only

  • 产品介绍
  • merck millipore,默克密理博,AB3077,Anti-Aquaporin 8 Antibody, colon & pancreas only

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3077
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Aquaporin 8 Antibody, colon & pancreas only
    Alternate Names
    • AQP8
    背景信息 Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. Aquaporin-0 or MIP26 (major intrinsic protein 26 kDa), and Aquaporin-1 (purified from red cells) also called CHIP-28 (channel forming integral protein, 28 kDa; 268 AA; gene locus 7p14) has been the foundation of the growing family of aquaporins. The lens specific Aquaporin-0 represents up to 80% of total lens membrane protein. Defects in MIP26 are a cause of autosomal dominant cataract. The cataract Fraser mutation (CAT-FR or Shriveled) is a transposon-induced splicing error that substitutes a long terminal repeat sequence for the c-terminus of MIP. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane. A new water channel, Aquaporin-8, has been identified in rat pancreas and testis by homology cloning (Koyama et al., 1997). Aquaporin-8 (263 aa; 28 kDa) is also found in liver, colon and salivary glands. Aquaporin-8 (APQ8) is expressed in all stages of spermatogenesis. Unlike other AQP, AQP8 has unusually long N-terminus and a short C-terminus. AQP families of proteins are predicted to contain six transmembrane domains. The N and C-terminus are predicted to be cytoplasmic. AQP8 has significant homology to various AQPs: g-TIP (plant water channel, 37%); AQP2 and MIP (37%), AQP1, AQP4, and AQP5 (30-34%); AQP3 (26%). AQP8 does not facilitate glycerol transport.
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS with 0.1% BSA.
    应用
    应用 This Anti-Aquaporin 8 Antibody, colon & pancreas only is validated for use in ELISA, WB for the detection of Aquaporin 8.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1-10 μg/mL using ECL

    ELISA: 0.5-1.0 μg/mL

    Immunohistochemistry: We recommend using the affinity purified antibody at 2-10 μg/mL in paraformaldehyde fixed sections of tissues.

    *Note: It is recommended that 0.5-1% milk is used in all primary/secondary antibody-enzyme conjugate incubations in order to diminish non-specific binding.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 A 16 AA synthetic peptide within the C-terminal domain of rat Aquaporin-8 (Koyama et al. 1997; Ishibashi et al. 1997) was selected for antibody production. This domain is predicted to be cytoplasmic.
    表位 colon & pancreas only
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Aquaporin 8. The immunogen peptide is unique to Aquaporin-8 without significant homology to other Aquaporins.

    SPECIES REACTIVITIES: Rat. The peptide has 93% homology with the mouse Aquaporin-8 but species reactivity has not been tested.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001169.2
    Entrez基因汇总 Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues.
    基因符号
    • Aquaporin-8
    • AQP8
    • AQP-8
    UniProt编号
    • O94778
    UniProt汇总 FUNCTION: SwissProt: O94778 # Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.
    SIZE: 261 amino acids; 27381 Da
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Expressed only in pancreas and colon.
    DOMAIN: SwissProt: O94778 Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
    SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB3077,Anti-Aquaporin 8 Antibody, colon & pancreas only

上一件merck millipore产品：merck millipore,默克密理博,MAB5456,Anti-Gonadotropin-Releasing Hormone Antibody, NT, clone HU11B
下一件merck millipore产品：merck millipore,默克密理博,19-123MG,Staurosporine


相关产品

merck millipore,默克密理博,CBL605,Rat IgG2a Negative Control, clone DD13 merck millipore,默克密理博,CBL605,Rat IgG2a Negative Control, clone DD13

merck millipore,默克密理博,S22-100ML,Sheep Serum merck millipore,默克密理博,S22-100ML,Sheep Serum

merck millipore,默克密理博,539131,Protease Inhibitor Cocktail Set I - Calbiochem merck millipore,默克密理博,539131,Protease Inhibitor Cocktail Set I - Calbiochem

merck millipore,默克密理博,RADPCMAG-82K,MILLIPLEX MAP Rat Adipocyte Panel - Metabolism Assay merck millipore,默克密理博,RADPCMAG-82K,MILLIPLEX MAP Rat Adipocyte Panel - Metabolism Assay

merck millipore,默克密理博,MAB5456,Anti-Gonadotropin-Releasing Hormone Antibody, NT, clone HU11B merck millipore,默克密理博,MAB5456,Anti-Gonadotropin-Releasing Hormone Antibody, NT, clone HU11B

merck millipore,默克密理博,19-123MG,Staurosporine merck millipore,默克密理博,19-123MG,Staurosporine

merck millipore,默克密理博,539677,PKCθ, His•Tag, Human, Recombinant, S. frugiperda merck millipore,默克密理博,539677,PKCθ, His•Tag, Human, Recombinant, S. frugiperda

merck millipore,默克密理博,422711,KN-93, Water-Soluble - Calbiochem merck millipore,默克密理博,422711,KN-93, Water-Soluble - Calbiochem

merck millipore,默克密理博,04-1055,Anti-Atg7 Antibody, clone EP1759Y, rabbit monoclonal merck millipore,默克密理博,04-1055,Anti-Atg7 Antibody, clone EP1759Y, rabbit monoclonal

merck millipore,默克密理博,ABD73,Anti-Lefty Antibody merck millipore,默克密理博,ABD73,Anti-Lefty Antibody


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部