merck millipore,默克密理博,AB2297,Anti-phospho GluR2 (Tyr876) Antibody

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merck millipore,默克密理博,AB2297,Anti-phospho GluR2 (Tyr876) Antibody
产品名称：Anti-phospho GluR2 (Tyr876) Antibody
产品型号：AB2297
Anti-phospho GluR2 (Tyr876) Antibody detects level of phospho GluR2 (Tyr876) & has been published & validated for use in WB.

merck millipore,默克密理博,AB2297,Anti-phospho GluR2 (Tyr876) Antibody

产品介绍

merck millipore,默克密理博,AB2297,Anti-phospho GluR2 (Tyr876) Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB2297
描述	Anti-phospho GluR2 (Tyr876) Antibody
Alternate Names	GluA2 Glutamate receptor 2 GluR-2 AMPA-selective glutamate receptor 2 GluR-B GluR-K2 Glutamate receptor ionotropic, AMPA 2
背景信息	Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Phosphorylation of tyrosine 876 (Tyr876) near the C terminus of GluR2 is thought to be instrumental in the control of AMPA receptor function and synaptic plasticity.

产品信息
格式	Affinity Purified
控制	Phosphatase untreated and treated rat brain tissue lysate
演示	Purified rabbit polyclonal buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

应用
应用	Anti-phospho GluR2 (Tyr876) Antibody detects level of phospho GluR2 (Tyr876) & has been published & validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	Linear peptide corresponding to rat GluR2 phosphorylated at Tyr869, Tyr873, and Tyr876.
表位	Phosphorylated Tyr869, Tyr873, and Tyr876
宿主	Rabbit
特异性	This antibody recognizes GluR2 phosphorylated at Tyr869, Tyr873, and Tyr876.
同种型	IgG
品种反应性	Rat
Species Reactivity Note	Demonstrated to react with rat.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_058957
Entrez基因汇总	Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq].
基因符号	Glur2 Gria2
修改	Phosphorylation
纯化方法	Affinity purified
UniProt编号	P19491
UniProt汇总	FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. SUBUNIT STRUCTURE: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4 (by similarity). Interacts with CACNG2, PRKCABP, GRIP1 and GRIP2. Interacts with NSF via its C-terminus. Part of a complex containing GRIA2, NSF and NAPA and/or NAPB. Interacts with PICK1 (via PDZ domain) (by similarity). Interacts with GRIA1 and TMEM90B (by similarity). Interacts with LRFN1. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Note: Interaction with CACNG2 promotes cell surface expression. TISSUE SPECIFICITY: Detected in forebrain. Detected in dendrites of neuronal cells. DEVELOPMENTAL STAGE: Detected at low levels in newborns. Levels increase strongly and are highest in hippocampus from 8 to 14 day old animals. Detected at intermediate levels at day 42 (at protein level). POST-TRANSLATIONAL MODIFICATION: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (by similarity). MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. RNA EDITING: Edited at position 607. Fully edited in the brain. Heteromerically expressed edited GLUR2 (R) receptor complexes are impermeable to calcium, whereas the unedited (Q) forms are highly permeable to divalent ions (by similarity).

产品使用声明
质量保证	Evaluated by Western Blot in phosphatase untreated and treated rat brain tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected phosphorylated GluR2 on 10 µg of phosphatase untreated and treated rat brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µL

merck millipore,默克密理博,AB2297,Anti-phospho GluR2 (Tyr876) Antibody

上一件merck millipore产品：merck millipore,默克密理博,ABC419,Anti-TK1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,MABC154,Anti-RRM2 Antibody, clone 4D1.2

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