merck millipore,默克密理博,AB1891,Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	WB, IHC	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	AB1891
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop
Alternate Names	CX3CR1
背景信息	CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively (1-4). The seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by facktokine (6). CX3CR1 mediates leukocyte migration and adhesion.

产品信息
格式	Purified
演示	Purified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.

应用
应用	Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop is an antibody against C-X-X-X-C Chemokine Receptor 1 for use in IH & WB.
主要应用	Western Blotting Immunohistochemistry
应用说明	Western blot: 1:500 (THP cell lysate can be used as positive control and an approximately 50 kDa band can be detected) Immunohistochemistry in frozen sections Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide from the extracellular loop of human CX3CR1.
表位	extracellular loop
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	Specific for human C-X-X-X-C Chemokine Receptor 1 (CX3CR1) at the Extracellular loop. The sequence is identical to that of rat and differs from that of mouse by only one amino acid.
品种反应性	Human
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_001337.3
基因符号	CMKBLR1 CX3CR1 CMKDR1 GPR13 CMK-BRL-1 V28 GPRV28 CMKBRL1 CCRL1
UniProt编号	P49238
UniProt汇总	FUNCTION: SwissProt: P49238 # Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV coreceptors than isoform 1. SIZE: 355 amino acids; 40396 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in lymphoid and neural tissues. SIMILARITY: SwissProt: P49238 ## Belongs to the G-protein coupled receptor 1 family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store at 2-8°C for up to 12 months.

包装信息
数量	100 µg

merck millipore,默克密理博,AB1891,Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop

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