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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB16518 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-SODD Antibody, NT 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. 应用 应用 Detect SODD using this Anti-SODD Antibody, N-terminus validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:500 to 1:2000
HeLa and THP-1 whole cell lysate can be used as positive control and an approximately 60 kDa band can be detected.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Rabbit anti-SODD (N-terminal) polyclonal antibody was raised against a peptide corresponding to amino acids 2 to 16 of human SODD (Jiang et al. 1999). 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5 and DR6 were recently indentified. The cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of the these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains (Jiang et al. 1999). SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines. 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004874.2
Entrez基因汇总 The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. 基因符号 - BAG-4
- BAG4
- SODD
- Bag-4
UniProt编号 - O95429
UniProt汇总 FUNCTION: SwissProt: O95429 # Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling.
SIZE: 457 amino acids; 49594 Da
SUBUNIT: Binds to the ATPase domain of HSP70/HSC chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: SwissProt: O95429 ## Contains 1 BAG domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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