merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3802,Anti-53BP1 Antibody, clone BP13

  • merck millipore,默克密理博,MAB3802,Anti-53BP1 Antibody, clone BP13

    产品名称：Anti-53BP1 Antibody, clone BP13
    产品型号：MAB3802
    Detect 53BP1 also known as p53 Binding Protein 1 with Anti-53BP1 Antibody, clone BP13 (Mouse Monoclonal Antibody) validated in IF & WB.

    merck millipore,默克密理博,MAB3802,Anti-53BP1 Antibody, clone BP13

  • 产品介绍
  • merck millipore,默克密理博,MAB3802,Anti-53BP1 Antibody, clone BP13

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3802
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-53BP1 Antibody, clone BP13
    Alternate Names
    • p53 Binding Protein 1
    背景信息 P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, and maintaining genomic stability. It is sequence specific transcription factor that plays a central role in the the response of mammalian cells to genotoxic stress. Also, 53BP1 localizes to kinetochores in mitotic cells, suggesting a potential function in mitotic checkpoint signaling.
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Liquid in PBS, containing sodium azide.
    应用
    应用 Detect 53BP1 also known as p53 Binding Protein 1 with Anti-53BP1 Antibody, clone BP13 (Mouse Monoclonal Antibody) validated in IF & WB.
    主要应用
    • Western Blotting
    应用说明 Western blot. Recognizes a protein of >250 kD. Suggested dilution buffer is TBST. Suggested blocking buffer is 5% non-fat dry milk.

    Immunoprecipitation. Expected size in immunoblot is >250 kD. Suggested lysis buffer is NETN. Suggested capture agent is Protein A + rabbit anti-mouse linker antibody.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Recombinant human 53BP1 proteins.
    克隆 BP13
    宿主 Mouse
    特异性 53BP1
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005657.1
    基因符号
    • FLJ41424
    • TP53BP1
    • 53BP1
    • MGC138366
    • p202
    • p53BP1
    UniProt编号
    • Q12888
    UniProt汇总 FUNCTION: SwissProt: Q12888 # May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage.
    SIZE: 1972 amino acids; 213574 Da
    SUBUNIT: Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H3 that has been methylated on 'Lys-79'. Does not bind unmethylated histone H3.
    SUBCELLULAR LOCATION: Nucleus. Kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks.
    PTM: Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. & Phosphorylated in an ATM-dependent manner in response to DNA damage.
    SIMILARITY: SwissProt: Q12888 ## Contains 2 BRCT domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3802,Anti-53BP1 Antibody, clone BP13

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