merck millipore,默克密理博,AB1566,Anti-Substance P Antibody, pain

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	RIA, IH(P)	Rb	Serum	Polyclonal Antibody

描述
产品目录编号	AB1566
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Substance P Antibody, pain
背景信息	Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapse. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.

产品信息
格式	Serum
控制	Spinal Cord.
演示	Rabbit polyclonal serum containing 0.1% sodium azide.

应用
应用	This Anti-Substance P Antibody, pain is validated for use in IH(P), RIA for the detection of Substance P.
主要应用	Radioimmunoassay Immunohistochemistry (Paraffin)
应用说明	RIA: 1:10,000 dilution from a previous lot was used in radioimmunioassay. 80% binding detects at least 5 pg/mL. Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	Substance P
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	Substance P
品种反应性	RatHumanMouse
Species Reactivity Note	Human, mouse, and rat.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_003182.1
Entrez基因汇总	This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.
基因符号	TAC2 TAC1 NKNA Hs.2563 NK2 PPT NKA
纯化方法	Unpurified
UniProt编号	P20366
UniProt汇总	FUNCTION: SwissProt: P20366 # Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. SIZE: 129 amino acids; 15003 Da SUBCELLULAR LOCATION: Secreted. SIMILARITY: SwissProt: P20366 ## Belongs to the tachykinin family.

产品使用声明
质量保证	Immunohistochemistry(paraffin): Substance P (AB1566) representative staining pattern/morphology in Alzheimer’s brain. Tissue pretreated with Citrate pH6.0, antigen retrieval. Antibody diluted to 1:100. IHC-Paraffin Staining With Citrate pH 6.0 Epitope Retrieval: Alzheimer’s Brain.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt.

包装信息
数量	100 µL

merck millipore,默克密理博,AB1566,Anti-Substance P Antibody, pain

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