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品种反应性 主要应用 宿主 格式 抗体类型 F, H, M, R WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1555 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-NMDAR2A Antibody 产品信息 格式 Serum 控制 - NMDAR2A is present in high concentrations in the hippocampus
演示 Rabbit antiserum. Liquid, no preservatives. 应用 应用 This Anti-NMDAR2A Antibody is validated for use in IP, WB for the detection of NMDAR2A. 主要应用 - Western Blotting
不建议的应用 - Immunohistochemistry
应用说明 Western blotting*: 1:1,000-1:5,000 for ECL. If using labled protein-A for detection: 1:200.
* See suggested protocol
Immunoprecipitation using solubilized hippocampal slices. 3μL will (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200μg rat brain.
Not suggested for use in immunohistochemistry.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 C-Terminal Fusion Protein of the NMDAR2A (30 kDa), aa 1253-1391. 宿主 Rabbit 特异性 NMDAR2A. By Western blot it recognizes a 180 kDa band in rat brain membranes. 品种反应性 FishHumanMouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000833.2
Entrez基因汇总 N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). 基因符号 - NR2A
- GRIN2A
- hNR2A
- Glutamate
- NMDAR2A
UniProt编号 - Q12879
UniProt汇总 FUNCTION: SwissProt: Q12879 # NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
SIZE: 1464 amino acids; 165283 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: Q12879 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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