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描述 产品目录编号 AG252 品牌系列 Chemicon®
商名 - Chemicon
描述 GAD, control peptide for AB1511 概述 Synthetic peptide corresponding to amino acid residues Cys+ 572-585 of rat GAD65 (Erlander et al., 1991). The amino acid sequence is wholly conserved in rat GAD67, and the peptide is located at the C-terminus in both forms of the enzyme. Sequence: [C]DFLIEEIERLGQDL. Alternate Names - GAD
产品信息 演示 White lyophilized powder. Soluble in water. 应用 主要应用 - Cell Function Assay
应用说明 Antibody blocking (AB1511)
Optimal working dilution must be determined by the end user.生物信息 纯度 >80% 品种 Rat Entrez基因编号 - NM_000818.1
Entrez基因汇总 This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. 基因符号 - EC 4.1.1.15
- GAD2
- MGC161607
- GAD65
- MGC161605
- GAD-65
UniProt编号 - Q05329
UniProt汇总 FUNCTION: SwissProt: Q05329 # Catalyzes the production of GABA.
COFACTOR: Pyridoxal phosphate.
SIZE: 585 amino acids; 65411 Da
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
PTM: Phosphorylated; which does not affect kinetic parameters or subcellular location. & Palmitoylated; which is required for presynaptic clustering.
SIMILARITY: SwissProt: Q05329 ## Belongs to the group II decarboxylase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Long term storage at -20°C in a sealed container with desiccant for up to 12 months after date of receipt. 包装信息 数量 50 µg
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