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  • merck millipore,默克密理博,AB15508,Anti-Iron Regulatory Protein 2 Antibody

  • merck millipore,默克密理博,AB15508,Anti-Iron Regulatory Protein 2 Antibody

    产品名称：Anti-Iron Regulatory Protein 2 Antibody
    产品型号：AB15508
    Detect Iron Regulatory Protein 2 using this Anti-Iron Regulatory Protein 2 Antibody validated for use in ELISA & WB.

    merck millipore,默克密理博,AB15508,Anti-Iron Regulatory Protein 2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB15508,Anti-Iron Regulatory Protein 2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWB, ELISARbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB15508
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Iron Regulatory Protein 2 Antibody
    Alternate Names
    • IRP-2
    背景信息 Iron regulatory proteins (IRP-1 and IRP-2) are cytoplasmic mRNA-binding proteins that control intracellular iron levels by regulating the translation of ferritin, Tfrs, and other proteins congaing iron-responsive element (IRE) located at the 5'-UTR. IRP binds to IREs with high affinity in situation of iron starvation. Binding of IRP to IRE of ferritin represses its transcription. However, when cells are iron replete, IRPs lose their capacity to bind IREs, allowing efficient translation of ferritin and reducing Tfr mRNA half-life. Although IRP1 and IRP-2 share significant protein sequence homology, they differ in tissue distribution and mode of regulation. IRP-2/IRE-BP2 (rat/human 963 aa) is relatively less abundant than IRP-1 and lacks aconitase activity. It has a unique 73-aa insertion in the N-terminus. In the presence of high iron levels, IRP-2 is rapidly targeted to proteasome-mediated degradation. Although, both IRPs bind the consensus IREs, it is also shown that IRP-2 can recognize an exclusive IRE subset.
    产品信息
    格式 Purified
    演示 Liquid in PBS with 0.1% BSA and 0.05% sodium azide.
    应用
    应用 Detect Iron Regulatory Protein 2 using this Anti-Iron Regulatory Protein 2 Antibody validated for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1-10 µg/mL using ECL.
    Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL
    ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.
    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide near the N-terminus of human/rat/mouse IRP-2.
    宿主 Rabbit
    特异性 Iron regulatory protein 2 (IRP-2). The immunogen sequence has no significant homology with IRP-1.
    品种反应性 RatHumanMouse
    Species Reactivity Note The immunogen sequence is 100% conserved in human, rat, and mouse IRP-2.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_004136.2
    基因符号
    • ACO3
    • IREB2
    • IRP2AD
    • FLJ23381
    • IRP2
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P48200
    UniProt汇总 FUNCTION: SwissProt: P48200 # Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
    COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity).
    SIZE: 963 amino acids; 105012 Da
    SUBCELLULAR LOCATION: Cytoplasm.
    SIMILARITY: SwissProt: P48200 ## Belongs to the aconitase/IPM isomerase family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB15508,Anti-Iron Regulatory Protein 2 Antibody

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