merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1085,Anti-IL-7Ra (CD127) Antibody, extracellular

  • merck millipore,默克密理博,06-1085,Anti-IL-7Ra (CD127) Antibody, extracellular

    产品名称：Anti-IL-7Ra (CD127) Antibody, extracellular
    产品型号：06-1085
    Use Anti-IL-7Ra (CD127) Antibody, extracellular (Rabbit Polyclonal Antibody) validated in ELISA, WB, FC to detect IL-7Ra (CD127) also known as CD127 antigen, interleukin 7 receptor.

    merck millipore,默克密理博,06-1085,Anti-IL-7Ra (CD127) Antibody, extracellular

  • 产品介绍
  • merck millipore,默克密理博,06-1085,Anti-IL-7Ra (CD127) Antibody, extracellular

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFC, ELISA, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1085
    描述 Anti-IL-7Ra (CD127) Antibody, extracellular
    Alternate Names
    • interleukin 7 receptor isoform H5-6
    • CD127 antigen
    • interleukin 7 receptor
    • interleukin 7 receptor alpha chain
    背景信息 Interleukin 7 receptor (IL7R or IL7Ra) also known as CD127 is a type I cytokine receptor. IL-7R is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukin 2, 4, 7, 9, and 15. IL-7R plays a critical role in the V(D)J recombination during lymphocyte development as well as a role in controlling the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID) as well as the pathogenesis of multiple sclerosis.
    产品信息
    格式 Affinity Purified
    控制
    • K562 cell lysate
    演示 Purified rabbit polyclonal in PBS with 0.09% sodium azide.
    应用
    应用 Use Anti-IL-7Ra (CD127) Antibody, extracellular (Rabbit Polyclonal Antibody) validated in ELISA, WB, FC to detect IL-7Ra (CD127) also known as CD127 antigen, interleukin 7 receptor.
    主要应用
    • Flow Cytometry
    • ELISA
    • Western Blotting
    应用说明 Flow Cytometry Analysis: 5 µg/mL from a previous lot detected IL-7Ra in lymphocytes.

    ELISA: A previous lot of this antibody was confirmed by ELISA by an independent laboratory.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human IL-7Ra at and around the extracellular domain.
    表位 Extracellular Domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the extracellular domain of IL-7Ra.
    May detect various isoforms of IL-7Ra (see molecular weight).
    品种反应性 Human
    Species Reactivity Note Proven to react with human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_002176
    Entrez基因汇总 The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukin 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq]
    基因符号
    • ILRA
    • IL7R
    • CD127
    • CDW127
    • CDw127
    • IL-7R-alpha
    • IL7RA
    纯化方法 Affinity Purfied
    UniProt编号
    • P16871
    UniProt汇总 FUNCTION: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

    SUBUNIT STRUCTURE: The IL7 receptor is an heterodimer of IL7R and IL2RG. The TSLP receptor is an heterodimer of CRLF2 and IL7R.

    SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.

    Isoform 3: Cell membrane; Single-pass type I membrane protein.

    Isoform 4: Secreted.

    DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

    The box 1 motif is required for JAK interaction and/or activation.

    INVOLVEMENT IN DISEASE: Defects in IL7R are a cause of autosomal recessive severe combined immunodeficiency T-cell-negative/B-cell-positive/NK cell-positive (T-/B+/NK+ SCID) [MIM:608971]. SCID refers to a genetically and clinically group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms, including Candida albicans, Pneumocystis carinii, and cytomegalovirus, among many others. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.

    A genetic variation in transmembrane domain of IL7R is associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. Overtransmission of the major 'C' allele coding for Thr-244 are detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS.

    SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 4 subfamily.

    Contains 1 fibronectin type-III domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in K562 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected IL-7Ra on 10 µg of K562 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-1085,Anti-IL-7Ra (CD127) Antibody, extracellular

上一件merck millipore产品：merck millipore,默克密理博,SF-2602,PAK1; Human, Cyanine 5 RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,WBKLS0050,Immobilon Western HRP 底物，2 x 25 mL


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