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品种反应性 主要应用 宿主 格式 抗体类型 M IHC, ICC Ch Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15454 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Proteolipid Protein Antibody Alternate Names - PLP
产品信息 格式 Affinity Purified 演示 Liquid in PBS, pH 7.2 with 0.02% sodium azide. 应用 应用 Detect Proteolipid Protein using this Anti-Proteolipid Protein Antibody validated for use in IC, IH. 主要应用 - Immunohistochemistry
- Immunocytochemistry
应用说明 Immunohistochemistry: 1:100-1:200 using 2% paraformaldehyde fixed tissue.
Immunocytochemistry: 1:100-1:200 using 2% paraformaldehyde fixed cells.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to human/mouse PLP protein. 宿主 Chicken 特异性 PLP [Proteolipid Protein] 品种反应性 Mouse Species Reactivity Note Other species have not yet been tested. It is expected that the antibody will also react with human due to immunogen sequence similarity. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_199478.1
- NM_000533.3
Entrez基因汇总 This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene. 基因符号 - Lipophilin
- PLP1
- lipophilin
- MMPL
- PLP/DM20
- PLP
- PMD
- SPG2
纯化方法 Immunoaffinity purified UniProt编号 - P60201
UniProt汇总 FUNCTION: SwissProt: P60201 # This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
SIZE: 277 amino acids; 30077 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DISEASE: SwissProt: P60201 # Defects in PLP1 are the cause of Pelizaeus-Merzbacher disease (PMD) [MIM:312080]. PMD is an X-linked neurologic disorder of myelin metabolism. It is characterized by early impairment of motor development (during the first three months of life) and, later, by the development of abnormal movements and progressive spastic paraplegia. & Defects in PLP1 are the cause of spastic paraplegia type 2 (SPG2) [MIM:312920]. SPG2 is a form of X-linked hereditary spastic paraplegia (HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Additional features include nystagmus, dysarthria and mental retardation, that are found in the complicated form of spastic paraplegia.
SIMILARITY: SwissProt: P60201 ## Belongs to the myelin proteolipid protein family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. 包装信息 数量 500 µL
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