merck millipore,默克密理愽
  • merck millipore,默克密理博,05-830,Anti-Neurofilament L Antibody, clone DA2

  • merck millipore,默克密理博,05-830,Anti-Neurofilament L Antibody, clone DA2

    产品名称：Anti-Neurofilament L Antibody, clone DA2
    产品型号：05-830
    This Anti-Neurofilament L Antibody, clone DA2 is validated for use in WB, IH for the detection of Neurofilament.

    merck millipore,默克密理博,05-830,Anti-Neurofilament L Antibody, clone DA2

  • 产品介绍
  • merck millipore,默克密理博,05-830,Anti-Neurofilament L Antibody, clone DA2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rb, Av, B, H, M, Po, RIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-830
    Replaces 04-1112
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Neurofilament L Antibody, clone DA2
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 This Anti-Neurofilament L Antibody, clone DA2 is validated for use in WB, IH for the detection of Neurofilament.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    生物信息
    免疫原品种 Purified and enzymatically dephosphorylated pig neurofilament, light chain
    克隆 clone DA2
    宿主 Mouse
    特异性 neurofilament, light chain
    同种型 IgG1
    品种反应性 RabbitAvianBovineHumanMousePigRat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_006158
    基因符号
    • NFL
    • NEFL
    • NF68
    • CMT1F
    • NF-L
    • CMT2E
    纯化方法 Protein G purfied
    UniProt编号
    • P07196
    UniProt汇总 FUNCTION: SwissProt: P07196 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
    SIZE: 543 amino acids; 61517 Da
    DOMAIN: SwissProt: P07196 The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions.
    PTM: O-glycosylated (By similarity).
    DISEASE: SwissProt: P07196 # Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is characterized by onset in infancy or childhood (range 1 to 13 years). & Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 2E (CMT2E) [MIM:607684]. CMT2E is an autosomal dominant form of Charcot-Marie-Tooth disease type 2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
    SIMILARITY: Belongs to the intermediate filament family.
    MISCELLANEOUS: NF-L is the most abundant of the three neurofilament proteins and, as the other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from a rat brain microsomal preparation
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-830,Anti-Neurofilament L Antibody, clone DA2

上一件merck millipore产品：merck millipore,默克密理博,AB15454,Anti-Proteolipid Protein Antibody
下一件merck millipore产品：merck millipore,默克密理博,ABE252,Anti-Nanos homolog 2 Antibody


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