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品种反应性 主要应用 宿主 格式 抗体类型 Ht, M, R WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB10533 描述 Anti-LMX-1 Antibody Alternate Names - LIM/homeobox protein LMX1A
- LIM homeobox transcription factor 1, alpha
- LIM/homeobox protein 1.1
背景信息 LMX-1 is a transcription factor that belongs to the LIM-homeodomain (LIM-HD) transcription factor family. It is induced within the ventral midbrain as a response to early signaling. LMX-1 is a necessary component for the development of the roof plate and for CNS dorsal cell date specification and the development of vertebrae. It is Expressed in roof plate, an organizational locus found in the dorsal CNS that functions to moderate the differentiation and specification of adjacent neurons through the secretion of signaling molecules such as WNT and BMP. Recent studies have indicated that LMX-1 has high potential for stimulating the production of mesencephalic dopamine neurons(mesDA) for the therapeutic treatment Parkinson disease, a condition characterized by dopaminergic neurotransmission decline resulting from the progression of mesDA neuronal degeneration within the substantia nigra pars compacta (SN). 产品信息 格式 Serum 控制 - Mouse testis tissue lysate
演示 Unpurified rabbit polyclonal serum containing 0.05% sodium azide. 应用 应用 Anti-LMX-1 Antibody is an antibody against LMX-1 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the C-terminus of hamster LMX-1. 表位 C-terminus 宿主 Rabbit 特异性 This antibody recognizes LMX-1. 同种型 IgG 品种反应性 HamsterMouseRat Species Reactivity Note Demonstrated to react with mouse and rat. Predicted to react with hamster based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - AAB62320
基因符号 - LMX1
- LMX-12
- LMX1.1
- LMX-1.1
纯化方法 Unpurified UniProt编号 - Q04650
UniProt汇总 FUNCTION: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).
SUBCELLULAR LOCATION: Nucleus.
SEQUENCE SIMILARITIES: Contains 1 homeobox DNA-binding domain.
Contains 2 LIM zinc-binding domains.产品使用声明 质量保证 Evaluated by Western Blot in mouse testis tissue lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected LMX-1 on 10 µg of mouse testis tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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