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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB10516 描述 Anti-Angiopoietin-1 Antibody Alternate Names - peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
- Hepatic fibrinogen/angiopoietin-related protein
- PPARG angiopoietin related protein
- angiopoietin-like 4
- angiopoietin-like 4 protein
- angiopoietin-related protein 4
- fasting-induced adipose factor
- hepatic angiopoietin-related protein
背景信息 The remodelling of the primitive vasculature in mammals to form the mature cardiovascular system includes a number of factors directing endothelial cell development. Angiopoietin-1 is an angiogenic secreted protein that interacts with the endothelial specific Tie-2 receptor. It is primarily expressed in developing endothelial cells. During embryonic development, Ang-1 binds and induces tyrosine phosphorylation of Tie-2. Ang-1 appears to play a crucial role in mediating matrix and mesenchyme. It mediates blood vessel maturation and stability. Ang-1 may play a critical role in heart development. Ang-1 deficient mice mimic the phenotype exhibited by animals deficient in Tie-2. A homolog of Ang-1, termed Angiopoietin-2 may act as an antagonist for Ang-1 and Tie-2. Ang-1 and Ang-2 have ~60% sequence homology. 产品信息 格式 Purified 控制 - Mouse kidney lysate
演示 Rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Angiopoietin-1 Antibody is an antibody against Angiopoietin-1 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from mouse Angiopoietin-1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Angiopoietin-1. 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with human, mouse, and rat. 100% sequence homology to mouse, 95% sequence homology to rat, cow, dog, pig, horse, 90% sequence homology to human. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001146.3
基因符号 - pp1158
- ANGPTL2
- ARP4
- FIAF
- HFARP
- NL2
- PGAR
纯化方法 Antigen affinity purified UniProt编号 - O08538
UniProt汇总 FUNCTION: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation By similarity.
SUBUNIT STRUCTURE: Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix By similarity.
SUBCELLULAR LOCATION: Secreted. Secreted › extracellular space › extracellular matrix By similarity. Note: The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 By similarity.
TISSUE SPECIFICITY: Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
PTM: N-glycosylated.
INVOLVEMENT IN DISEASE: Found to be highly expressed in the early stages of collagen-induced arthritis (CIA).
Serum levels of ANGPTL4 are significantly lower in patients with diabetes type 2 than those in healthy subjects, suggesting that decreased ANGPTL4 could be a causative factor of this disease.
Produced in ischemic tissues in conditions such as critical leg ischemia. In tumors, ANGPTL4 could be produced in the hypoxic areas surrounding necrotic regions. High levels could be produced in tumor cells of conventional renal cell carcinoma. This molecule therefore seems to be a marker of conventional renal cell carcinoma.
SEQUENCE SIMILARITIES: Contains 1 fibrinogen C-terminal domain.产品使用声明 质量保证 Evaluated by Western Blot in mouse kidney lysate.
Western Blot Analysis: : 1:1,000 dilution of this lot detected Angiopoietin-1 on 10 µg of mouse kidney lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C for up to 12 months. 包装信息 数量 100 µg
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