merck millipore,默克密理愽
  • merck millipore,默克密理博,616373,Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem

  • merck millipore,默克密理博,616373,Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem

    产品名称：Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem
    产品型号：616373
    The Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylati More>>

    merck millipore,默克密理博,616373,Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616373,Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₁₄ClFN₆871307-18-5
    描述
    概述 A cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM). Displays significant selectivity over other related kinases (IC50 = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC50 = 700 nM and 8.5 µM, respectively).
    产品目录编号 616373
    品牌系列 Calbiochem®
    同义词 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
    参考
    参考 Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.
    产品信息
    CAS号 871307-18-5
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₂₁H₁₄ClFN₆
    化学配方 C₂₁H₁₄ClFN₆
    Molar Mass 404.8
    可逆 Y
    结构配方图像
    生物信息
    主靶 Tpl2 Kinase
    主靶IC50 50 nM against Tpl2 kinase
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616373,Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem

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