merck millipore,默克密理愽
  • merck millipore,默克密理博,205615,E-Cadherin Upregulator, ResEcad - Calbiochem

  • merck millipore,默克密理博,205615,E-Cadherin Upregulator, ResEcad - Calbiochem

    产品名称：E-Cadherin Upregulator, ResEcad - Calbiochem
    产品型号：205615
    A cell-permeable isoxazolocarboxamide compound that enhances the E-cadherin protein level in lung squamous cell carcinoma H520 and colorectal adenocarcinoma SW620 cells.

    merck millipore,默克密理博,205615,E-Cadherin Upregulator, ResEcad - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,205615,E-Cadherin Upregulator, ResEcad - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₇N₃O₃
    描述
    概述 A cell-permeable isoxazolocarboxamide compound that enhances the E-cadherin protein level in lung squamous cell carcinoma H520 and colorectal adenocarcinoma SW620 cells (6.3- and 10-fold, respectively; 10 µM for 24 h) in a dose-dependent manner (EC50 = 1.25 and 2.13 µM, respectively), resulting in an effective culture invasiveness reduction (by ~50% in SW620 invasion assays). The observed cellular E-cadherin protein upregulation correlates well with an increase in both cellular E-cadherin gene CHD1 transcription (10.2-fold increase in SW620 by RNA-Seq analysis;10 µM for 24 h) and histone H4 Lys9 acetylation (19- and 57-fold enhancement in H529 and SW620 cells, respectively; 10 µM for 24 h), although evidence indicates no direct inhibition of HDACs 1-11 activity by the compound and other cellular factors involved in histone acetylation regulation are the likely candidates as the direct drug target(s).
    产品目录编号 205615
    品牌系列 Calbiochem®
    同义词 5-(Furan-2-yl)-N-(pyridine-4-yl)butyl)isoxazole-3-carboxamide, E-Cadherin Expression Restorer
    参考
    参考 Stoops, S.L., et al. 2011. ACS Chem. Biol. 6, 452.
    产品信息
    形式 Off-white powder
    Hill配方 C₁₇H₁₇N₃O₃
    化学配方 C₁₇H₁₇N₃O₃
    Molar Mass 311.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,205615,E-Cadherin Upregulator, ResEcad - Calbiochem

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