merck millipore,默克密理愽
  • merck millipore,默克密理博,AB9962,Anti-P/CAF Antibody

  • merck millipore,默克密理博,AB9962,Anti-P/CAF Antibody

    产品名称：Anti-P/CAF Antibody
    产品型号：AB9962
    Anti-P/CAF Antibody is a Rabbit Polyclonal Antibody for detection of P/CAF also known as K(lysine) acetyltransferase 2B, P300/CBP-associated factor & has been validated in WB, ICC.

    merck millipore,默克密理博,AB9962,Anti-P/CAF Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB9962,Anti-P/CAF Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, H, M, RICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB9962
    描述 Anti-P/CAF Antibody
    Alternate Names
    • K(lysine) acetyltransferase 2B
    • P300/CBP-associated factor
    • Histone acetyltransferase PCAF
    • histone acetyltransferase KAT2B
    • Lysine acetyltransferase 2B
    • Histone acetylase PCAF
    • CREBBP-associated factor
    背景信息 P/CAF(sometimes called KAT2B) is a transcription cofactor with a histone acetyltransferase (HAT) activity. Consistent with this protein playing a direct role in transcriptional regulation, P/CAF can acetylate core histones H3 and H4, chromatin proteins HMG17 and HMG I(Y), as well as human immunodeficiency virus Tat, transcription factor MyoD, and general transcription factors TFIIE and TFIIF. A role for P/CAF in cell growth and differentiation is suggested by its interaction in vivo and in vitro with p300/CBP, two large nuclear proteins that bind to sequence-specific factors involved in cell growth/differentiation. A role for P/CAF in cell division is also suggested by data showing that this protein competes with E1A for binding sites in p300/CBP to counteract E1A's mitogenic activity.
    产品信息
    格式 Affinity Purified
    控制
    • HeLa nuclear extract
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-P/CAF Antibody is a Rabbit Polyclonal Antibody for detection of P/CAF also known as K(lysine) acetyltransferase 2B, P300/CBP-associated factor & has been validated in WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected P/CAF in HeLa cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of P/CAF.
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes P/CAF at the C-terminus.
    品种反应性 MonkeyHumanMouseRat
    Species Reactivity Note Demonstrated to react with Human, Mouse, Rat, and Monkey.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_003875
    Entrez基因汇总 Summary: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq].
    基因符号
    • KAT2B
    • GCN5
    • GCN5L
    • P/CAF
    • P
    • CAF
    • PCAF
    纯化方法 Affinity purified
    UniProt编号
    • Q92831
    UniProt汇总 FUNCTION: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.

    CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    SUBUNIT STRUCTURE: Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes tranactivation activity (By similarity). Interacts with EP300 and CREBBP. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM.

    SUBCELLULAR LOCATION: Nucleus (By similarity).

    TISSUE SPECIFICITY: Ubiquitously expressed but most abundant in heart and skeletal muscle.

    DOMAIN: The bromodomain mediates binding to HIV-1 Tat.

    SEQUENCE SIMILARITIES: Belongs to the GCN5 family. Contains 1 bromo domain.Contains 1 N-acetyltransferase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa nuclear extract.

    Western Blot Analysis: 1 µg/mL of this antibody detected P/CAF on 10 µg of HeLa nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB9962,Anti-P/CAF Antibody

上一件merck millipore产品：merck millipore,默克密理博,GF404,HumanKine BMP-7, Human Recombinant Xeno-Free
下一件merck millipore产品：merck millipore,默克密理博,234140,Collagenase Inhibitor I - Calbiochem


相关产品

merck millipore,默克密理博,AB4145,Anti-SIM2 Antibody merck millipore,默克密理博,AB4145,Anti-SIM2 Antibody

merck millipore,默克密理博,205615,E-Cadherin Upregulator, ResEcad - Calbiochem merck millipore,默克密理博,205615,E-Cadherin Upregulator, ResEcad - Calbiochem

merck millipore,默克密理博,SF-1980,CRTC1; Human, Cyanine 5 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1980,CRTC1; Human, Cyanine 5 RNA Detection Probe,SmartFlare

merck millipore,默克密理博,SF-727,miR-150-5p; Human, Cyanine 3, RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-727,miR-150-5p; Human, Cyanine 3, RNA Detection Probe,SmartFlare

merck millipore,默克密理博,GF404,HumanKine BMP-7, Human Recombinant Xeno-Free merck millipore,默克密理博,GF404,HumanKine BMP-7, Human Recombinant Xeno-Free

merck millipore,默克密理博,234140,Collagenase Inhibitor I - Calbiochem merck millipore,默克密理博,234140,Collagenase Inhibitor I - Calbiochem

merck millipore,默克密理博,6500-OP,OmniPur PBS Tablets - Calbiochem merck millipore,默克密理博,6500-OP,OmniPur PBS Tablets - Calbiochem

merck millipore,默克密理博,1125-OP,OmniPur Acridine Orange - CAS 10127-02-3 - Calbiochem merck millipore,默克密理博,1125-OP,OmniPur Acridine Orange - CAS 10127-02-3 - Calbiochem

merck millipore,默克密理博,MAB8002,Anti-Hepatitis E Virus Antibody, aa 434-457, clone 1E6 merck millipore,默克密理博,MAB8002,Anti-Hepatitis E Virus Antibody, aa 434-457, clone 1E6

merck millipore,默克密理博,197332,Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem merck millipore,默克密理博,197332,Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部