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merck millipore,默克密理博,AB1032,Anti-Versican Antibody, a.a. 535-598 of mouse versican
产品名称：Anti-Versican Antibody, a.a. 535-598 of mouse versican
产品型号：AB1032
This Anti-Versican Antibody, a.a. 535-598 of mouse versican is validated for use in IP, WB, IH(P) for the detection of Versican.
merck millipore,默克密理博,AB1032,Anti-Versican Antibody, a.a. 535-598 of mouse versican
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB1032 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Versican Antibody, a.a. 535-598 of mouse versican Alternate Names - GAG alpha Domain
背景信息 Versican is a large multi-domain chondroitin sulphate proteoglycan, is secreted by fibroblasts and other types of cells. It has a N-terminal hyaluronic acid (HA) binding domain. This domain has homology with the G1 and G2 domains of aggrecan, (G1 is the hyaluronic acid binding region), to cartilage link protein which stabilizes the binding of aggrecan to hyaluronic acid, and, to the hyaluronate receptor CD44. In addition, versican also has a lectin like domain, a C-terminal compliment repeat, and two EGF-like repeats, all of which can be found in aggrecan., Versican has an apparent molecular mass of ca. 1000 kDa, of which the core contributes 400 kDa from the 2409 amino acids, and the 12 -15 covalently attached chondroitin sulphate chains make up the rest. 产品信息 格式 Purified 控制 - Immunohistochemistry Positive control: surrounding cartilage, neural tube / brainWestern blotting positive control: newborn mouse brain
演示 Immunoglobulin was purified by affinity chromatography and is presented in PBS with no preservative Anti-GST has not been adsorbed. 应用 应用 This Anti-Versican Antibody, a.a. 535-598 of mouse versican is validated for use in IP, WB, IH(P) for the detection of Versican. 主要应用 - Western Blotting
应用说明 Immunohistochemistry (formalin fixed, paraffin embedded): 10 μg/mL. Tissues must be treated with Chondroitinase before staining {0.5U/mL in 100mM Tris-HCL pH 7.2-7.4, 30 minutes at room temperature} Then block and stain.
Western blotting: 0.5 μg/mL
Immunoprecipitation
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 GST fusion protein containing amino acids 535-598 of mouse versican. 表位 a.a. 535-598 of mouse versican 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Mouse versican GAG alpha domain 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004385.2
基因符号 - CSPG2
- VCAN
- GHAP
- DKFZp686K06110
- WGN
- PG-M
- WGN1
- ERVR
UniProt编号 - P13611
UniProt汇总 FUNCTION: SwissProt: P13611 # May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
SIZE: 3396 amino acids; 372820 Da
SUBUNIT: Interacts with FBLN1 (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Cerebral white matter. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas; isoform V2 is restricted to normal brain and gliomas; isoform V3 is found in all these tissues except medulloblastomas.
DEVELOPMENTAL STAGE: Disappears after the cartilage development.
DISEASE: SwissProt: P13611 # Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN.
SIMILARITY: SwissProt: P13611 ## Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 2 EGF-like domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 2 Link domains. & Contains 1 Sushi (CCP/SCR) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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下一件merck millipore产品：merck millipore,默克密理博,MABE167,Anti-SNAI1 Antibody, clone 10H4.1
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