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品种反应性 主要应用 宿主 格式 抗体类型 M WB, FC M Purified Monoclonal Antibody 描述 产品目录编号 04-973 描述 Anti-CD39 Antibody, clone 5F2 Alternate Names - CD39 antigen
- ectonucleoside triphosphate diphosphohydrolase 1
- ATPDase
- ecto-apyrase
- NTPDase-1
- Ecto-ATP diphosphohydrolase
- Lymphoid cell activation antigen
- NTPDase 1
- Ecto-apyrase
背景信息 Ectonucleoside triphosphate diphosphohydrolase 1 (NTDase 1 or CD39) belongs to the membrane-bound ecto-nucleoside triphosphates diphosphohydrolase family (E-NTPDases) that are characterized for their ability to hydrolyze nucleoside di- and triphosphates, such as ATP, in the presence of cations, i.e. CA2+ and Mg2+. CD39 is an important membrane protein containing two transmembrane domains and a large NTPDase active, extracellular region containing apyrase conserved regions. It is heavily glycosolated, having six known N-glycosolation sites, and functions on the plasma membrane’s outer surface. CD39 initiates the metabolism, of ATP and ADP to adenosine through a 2-step exzymatic reaction, providing extracellular adenosine for the purpose of regulating various inflammatory endpoints. It is a putative marker for B-cell activation and its expression has also been observed on NK-cells, dendritic cells, T-cells, and vascular endothelial cells. CD39 is a known inhibitor of ADP-induced platelet aggregation and may also play a role in angiogenesis. 产品信息 格式 Purified 控制 - BALB/c splenocytes
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-CD39 Antibody, clone 5F2 is validated for use in FC, WB for the detection of CD39. 主要应用 - Western Blotting
- Flow Cytometry
应用说明 Western Blot Analysis: A previous lot was used by an independent laboratory in WB. 生物信息 免疫原品种 Recombinant protein corresponding to mouse CD39. 表位 Unknown 克隆 5F2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes CD39. 同种型 IgG1κ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_033978
基因符号 - Ectoapyrase
- CD39
- Ecto-apyrase
纯化方法 Protein G purfied UniProt编号 - P55772
UniProt汇总 FUNCTION: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.
CATALYTIC ACTIVITY: ATP + 2 H2O = AMP + 2 phosphate.
COFACTOR: Calcium (By similarity).
MAGNESIUM: (By similarity).
SUBUNIT STRUCTURE: Homodimer; disulfide-linked (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SEQUENCE SIMILARITIES: Belongs to the GDA1/CD39 NTPase family.产品使用声明 质量保证 Evaluated by Flow Cytometry in BALB/c splenocytes.
Flow Cytometry Analysis: 0.1 µg/mL of this antibody detected CD39 in BALB/c splenocytes.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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