merck millipore,默克密理博,46-602MAG,MILLIPLEX MAP Phospho ERK/MAPK 1/2 (Thr185/Tyr187) Magnetic Bead MAPmate

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merck millipore,默克密理博,46-602MAG,MILLIPLEX MAP Phospho ERK/MAPK 1/2 (Thr185/Tyr187) Magnetic Bead MAPmate - Cell Signaling Single Plex
产品名称：MILLIPLEX MAP Phospho ERK/MAPK 1/2 (Thr185/Tyr187) Magnetic Bead MAPmate - Cell Signaling Single Plex
产品型号：46-602MAG
This MILLIPLEX MAP Phospho ERK/MAPK 1/2 (Thr185/Tyr187) Magnetic Bead MAPmate is a Cell Signaling Single Plex. The analyte available for this kit is Erk/MAPK 1/2 (Thr185/Tyr187).

merck millipore,默克密理博,46-602MAG,MILLIPLEX MAP Phospho ERK/MAPK 1/2 (Thr185/Tyr187) Magnetic Bead MAPmate - Cell Signaling Single Plex

产品介绍

merck millipore,默克密理博,46-602MAG,MILLIPLEX MAP Phospho ERK/MAPK 1/2 (Thr185/Tyr187) Magnetic Bead MAPmate - Cell Signaling Single Plex

重要规格表

可用的分析物	品种反应性	主要应用	检测方法
Erk/MAPK 1/2 (Thr185/Tyr187)	M, H	Mplex	Luminex xMAP

描述
产品目录编号	46-602MAG
商名	MILLIPLEX
描述	MILLIPLEX MAP Phospho ERK/MAPK 1/2 (Thr185/Tyr187) Magnetic Bead MAPmate - Cell Signaling Single Plex

产品信息
检测方法	Luminex xMAP
配置	Single Plex
板面类型	Cell Signaling

应用
应用	This MILLIPLEX MAP Phospho ERK/MAPK 1/2 (Thr185/Tyr187) Magnetic Bead MAPmate is a Cell Signaling Single Plex. The analyte available for this kit is Erk/MAPK 1/2 (Thr185/Tyr187).
主要应用	Multiplexing
应用说明	• An overnight (4°C) incubation is recommended for best results • This assay requires 25 µL diluted cell lysate per well • Please consult the buffer compatibility chart or protocol for appropriate buffer choice • 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)

生物信息
品种反应性	MouseHuman
可用的分析物	Erk/MAPK 1/2 (Thr185/Tyr187)
Entrez基因编号	NM_138957.2 NM_002745.4
Entrez基因汇总	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
基因符号	p41mapk MAPK1 PRKM2 MAPK2 p42-MAPK p38 ERK P42MAPK ERK2 p40 PRKM1 p41 ERK-2 ERT1
修改	Phosphorylation
UniProt编号	P28482
UniProt汇总	FUNCTION: SwissProt: P28482 # Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). COFACTOR: Magnesium (By similarity). SIZE: 360 amino acids; 41390 Da SUBUNIT: Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine- kinase activity. Interacts with HSF4. DOMAIN: SwissProt: P28482 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. PTM: Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.