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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Chp, H WB, ELISA Gt Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB10000 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CHIP/STUB1 Antibody Alternate Names - CHIP, STUB1
- CHIP
背景信息 U box domain E3 ubiquitin ligase. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association. Also, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. 产品信息 格式 Affinity Purified 控制 - Positive Control: Highly expressed in brain, heart, skelatal muscle, pancreas and placenta. Weak expression in kidney, liver and lung.
演示 Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. 应用 应用 This Anti-CHIP/STUB1 Antibody is validated for use in ELISA, WB for the detection of CHIP/STUB1. 主要应用 - Western Blotting
- ELISA
生物信息 免疫原品种 Peptide with sequence DAFISENGWVEDY, from the C-terminus of the protein sequence according to NP_005852. 宿主 Goat 品种反应性 ChimpanzeeHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005861.2
基因符号 - CHIP
- STUB1
- SDCCAG7
- NY-CO-7
- HSPABP2
- UBOX1
UniProt编号 - Q9UNE7
UniProt汇总 FUNCTION: SwissProt: Q9UNE7 # Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
SIZE: 303 amino acids; 34856 Da
SUBUNIT: Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
PTM: Auto-ubiquitinated (in vitro). & Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:SwissProt: Q9UNE7 # Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients.
SIMILARITY: SwissProt: Q9UNE7 ## Contains 3 TPR repeats. & Contains 1 U-box domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20°C. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,MAB3199,Anti-E-Cadherin Antibody, clone 67A4
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