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描述 概述 Recombinant, human ACE ectodomain (amino acids 30-1261) fused at the C-terminus to a His•Tag® sequence and expressed in NSO cells. ACE is a zinc metallopeptidase that cleaves the C-terminal dipeptide from angiotensin I to produce the potent vasopressor octapeptide angiotensin II. Inactivates bradykinin by the sequential removal of two C-terminal dipeptides. ACE is a type I membrane protein that exists in two isoforms, somatic and germinal. By SDS-PAGE, the apparent molecular mass of the glycosylated protein appears larger than 120 kDa under either reducing or non-reducing condition. 产品目录编号 176871 品牌系列 Calbiochem®
同义词 Peptidyl-Dipetidase A, ACE 参考 参考 Wakutani, Y., et al. 2002. Ann. N. Y. Acad. Sci. 977, 232.
Hu, J., et al. 2001. J. Biol. Chem. 276, 47863.
Kessler, S.P., et al. 2000. J. Biol. Chem. 275, 26259.
Soubrier, F. et al. 1998. Proc. Natl. Acad. Sci. USA. 85, 9386.产品信息 形式 Liquid 配方 In 75 mM NaCl, 12.5 mM Tris, 500 nM ZnCl₂, 40% glycerol, pH 7.5. Molar Mass 120000 生物信息 纯度 ≥95% by SDS-PAGE 特异活性 ≥1 unit/µg protein 浓缩标签 Please refer to vial label for lot-specific concentration
理化信息 污染物 Endotoxins: ≤1.0 EU/µg ACE 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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