merck millipore,默克密理博,580551,Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2

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merck millipore,默克密理博,580551,Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem
产品名称：Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem
产品型号：580551
Mixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase.

merck millipore,默克密理博,580551,Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem

产品介绍

merck millipore,默克密理博,580551,Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem

重要规格表

经验配方	CAS号
C₄₁H₆₆O₁₃	109946-35-2

描述
概述	Mixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C.
产品目录编号	580551
品牌系列	Calbiochem®

参考
参考	McCluskey, A., et al. 2002. J. Med. Chem. 45, 1151. Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328. Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395. Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387. Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3. Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662. Suganuma, M., et al. 1992. Toxicon 30, 873. MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137. Magae, J., et al. 1989. J. Antibiot. 42, 1290.

参考

McCluskey, A., et al. 2002. J. Med. Chem. 45, 1151.
Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395.
Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387.
Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3.
Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662.
Suganuma, M., et al. 1992. Toxicon 30, 873.
MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137.
Magae, J., et al. 1989. J. Antibiot. 42, 1290.

产品信息
CAS号	109946-35-2
具有ATP竞争性	N
形式	Lyophilized thin film
Hill配方	C₄₁H₆₆O₁₃
化学配方	C₄₁H₆₆O₁₃
Molar Mass	767.0
可逆	N
结构配方图像

生物信息
主靶	PP1
主靶IC₅₀	1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively
纯度	≥97% by HPLC

理化信息
细胞可渗透	N
溶解度	CHCl₃, EtOH, or MeOH

GHS安全信息
RTECS	WX1000000

安全信息
R相	R: 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed.
S相	S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Highly Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
避光	Protect from light
防潮	Protect from moisture
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. From Catalog: Desc. Field- removed ". . .and useful for studies involving protein phosphorylation" - removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase